2-(2-{2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenoxy}ethyl)benzoic acid

Base Information

Chemical Name:2-(2-{2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenoxy}ethyl)benzoic acid
CAS No.:1451261-85-0
Molecular Formula:C₂₃H₁₈ClNO₆S
Molecular Weight:471.918
Hs Code.:

Synonyms:2-(2-{2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenoxy}ethyl)benzoic acid

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Chemical Property of 2-(2-{2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenoxy}ethyl)benzoic acid

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Technology Process of 2-(2-{2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenoxy}ethyl)benzoic acid

There total 9 articles about 2-(2-{2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenoxy}ethyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1451261-84-9
methyl 2-(2-{2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenoxy}ethyl)benzoate

: 1451261-85-0
2-(2-{2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenoxy}ethyl)benzoic acid

Guidance literature:: With methanol; sodium hydroxide; at 20 ℃; for 16h;

Reference yield:

: 493-05-0
isochromane

: 1451261-85-0
2-(2-{2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenoxy}ethyl)benzoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: selenium(IV) oxide / 5,5-dimethyl-1,3-cyclohexadiene / 44 h / 140 °C

2: potassium hydroxide / diethyl ether / 12 h / 20 °C

3: diazomethyl-trimethyl-silane / methanol; tetrahydrofuran / 0 °C / Inert atmosphere

4: pyridine; p-toluenesulfonyl chloride / chloroform / 0 - 20 °C / Inert atmosphere

5: lithium bromide / acetone / 5 h / Inert atmosphere; Reflux

6: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

7: ammonium chloride; zinc / water; methanol / 1 h / 20 °C

8: pyridine / 16 h / 100 °C

9: sodium hydroxide; methanol / 16 h / 20 °C

With pyridine; methanol; selenium(IV) oxide; potassium carbonate; ammonium chloride; p-toluenesulfonyl chloride; potassium hydroxide; lithium bromide; sodium hydroxide; zinc; diazomethyl-trimethyl-silane; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; chloroform; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 4702-34-5
isochroman-1-one

: 1451261-85-0
2-(2-{2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenoxy}ethyl)benzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: potassium hydroxide / diethyl ether / 12 h / 20 °C

2: diazomethyl-trimethyl-silane / methanol; tetrahydrofuran / 0 °C / Inert atmosphere

3: pyridine; p-toluenesulfonyl chloride / chloroform / 0 - 20 °C / Inert atmosphere

4: lithium bromide / acetone / 5 h / Inert atmosphere; Reflux

5: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

6: ammonium chloride; zinc / water; methanol / 1 h / 20 °C

7: pyridine / 16 h / 100 °C

8: sodium hydroxide; methanol / 16 h / 20 °C

With pyridine; methanol; potassium carbonate; ammonium chloride; p-toluenesulfonyl chloride; potassium hydroxide; lithium bromide; sodium hydroxide; zinc; diazomethyl-trimethyl-silane; In tetrahydrofuran; methanol; diethyl ether; chloroform; water; N,N-dimethyl-formamide; acetone;