(7R,9R)-5,6-pineno-5'-((5-tert-butyl-2-(triuoromethylsulfonyl)phenyl)ethynyl)-2,2'-bipyridine

Base Information

Chemical Name:(7R,9R)-5,6-pineno-5'-((5-tert-butyl-2-(triuoromethylsulfonyl)phenyl)ethynyl)-2,2'-bipyridine
CAS No.:1434147-35-9
Molecular Formula:C₃₀H₂₉F₃N₂O₃S
Molecular Weight:554.633
Hs Code.:

Synonyms:(7R,9R)-5,6-pineno-5'-((5-tert-butyl-2-(triuoromethylsulfonyl)phenyl)ethynyl)-2,2'-bipyridine

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Chemical Property of (7R,9R)-5,6-pineno-5'-((5-tert-butyl-2-(triuoromethylsulfonyl)phenyl)ethynyl)-2,2'-bipyridine

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Technology Process of (7R,9R)-5,6-pineno-5'-((5-tert-butyl-2-(triuoromethylsulfonyl)phenyl)ethynyl)-2,2'-bipyridine

There total 5 articles about (7R,9R)-5,6-pineno-5'-((5-tert-butyl-2-(triuoromethylsulfonyl)phenyl)ethynyl)-2,2'-bipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 217966-72-8
4-(tert-butyl)-2-iodophenyltrifluoromethane sulfonate

: 1434147-30-4
(7R,9R)-5,6-pineno-5'-ethynyl-2,2'-bipyridine

: 1434147-35-9
(7R,9R)-5,6-pineno-5'-((5-tert-butyl-2-(triuoromethylsulfonyl)phenyl)ethynyl)-2,2'-bipyridine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/chem.201204216

Reference yield:

: 1434147-11-1
(7R,9R)-5,6-pineno-5'-bromo-2,2'-bipyridine

: 1434147-35-9
(7R,9R)-5,6-pineno-5'-((5-tert-butyl-2-(triuoromethylsulfonyl)phenyl)ethynyl)-2,2'-bipyridine

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 12 h / 80 °C / Inert atmosphere

2: potassium carbonate / methanol; dichloromethane / 3 h

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; 1: |Sonogashira Cross-Coupling / 3: |Sonogashira Cross-Coupling;
DOI:10.1002/chem.201204216

Reference yield:

: 34413-88-2
pinocarvone

: 1434147-35-9
(7R,9R)-5,6-pineno-5'-((5-tert-butyl-2-(triuoromethylsulfonyl)phenyl)ethynyl)-2,2'-bipyridine

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium acetate / acetic acid / 24 h / 120 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 12 h / 80 °C / Inert atmosphere

3: potassium carbonate / methanol; dichloromethane / 3 h

4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ammonium acetate; potassium carbonate; triethylamine; diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; acetic acid; 2: |Sonogashira Cross-Coupling / 4: |Sonogashira Cross-Coupling;
DOI:10.1002/chem.201204216