5-(3-aminopropylamino)-7-(3,5-dimethoxyphenylamino)imidazo[1,2-c]pyrimidine-8-carboxamide

Base Information

Chemical Name:5-(3-aminopropylamino)-7-(3,5-dimethoxyphenylamino)imidazo[1,2-c]pyrimidine-8-carboxamide
CAS No.:725235-19-8
Molecular Formula:C₁₈H₂₃N₇O₃
Molecular Weight:385.426
Hs Code.:

Synonyms:5-(3-aminopropylamino)-7-(3,5-dimethoxyphenylamino)imidazo[1,2-c]pyrimidine-8-carboxamide

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Chemical Property of 5-(3-aminopropylamino)-7-(3,5-dimethoxyphenylamino)imidazo[1,2-c]pyrimidine-8-carboxamide

Chemical Property:

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Technology Process of 5-(3-aminopropylamino)-7-(3,5-dimethoxyphenylamino)imidazo[1,2-c]pyrimidine-8-carboxamide

There total 6 articles about 5-(3-aminopropylamino)-7-(3,5-dimethoxyphenylamino)imidazo[1,2-c]pyrimidine-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₃₁N₇O₅

: 725235-19-8
5-(3-aminopropylamino)-7-(3,5-dimethoxyphenylamino)imidazo[1,2-c]pyrimidine-8-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2021.113393

Reference yield:

: 1388816-81-6
4-amino-2,6-dichloropyrimidine-5-carboxamide

: 725235-19-8
5-(3-aminopropylamino)-7-(3,5-dimethoxyphenylamino)imidazo[1,2-c]pyrimidine-8-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 80 °C

2: sodium hydrogencarbonate; sodium iodide / tert-butyl alcohol / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 80 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2021.113393

Reference yield:

: 4-amino-2-chloro-6-((3,5-dimethoxyphenyl)amino)pyrimidine-5-carboxamide

: 725235-19-8
5-(3-aminopropylamino)-7-(3,5-dimethoxyphenylamino)imidazo[1,2-c]pyrimidine-8-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; sodium iodide / tert-butyl alcohol / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 80 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2021.113393