3-(2-(4-hydroxy-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)phenoxy)propylphosphonic acid

Base Information

Chemical Name:3-(2-(4-hydroxy-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)phenoxy)propylphosphonic acid
CAS No.:1292305-62-4
Molecular Formula:C₃₅H₄₀F₆N₃O₈PS
Molecular Weight:807.748
Hs Code.:

3-(2-(4-hydroxy-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)phenoxy)propylphosphonic acid

Synonyms:3-(2-(4-hydroxy-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)phenoxy)propylphosphonic acid

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Chemical Property of 3-(2-(4-hydroxy-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)phenoxy)propylphosphonic acid

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Technology Process of 3-(2-(4-hydroxy-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)phenoxy)propylphosphonic acid

There total 8 articles about 3-(2-(4-hydroxy-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)phenoxy)propylphosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₇H₄₄F₆N₃O₈PS

: 1292305-62-4
3-(2-(4-hydroxy-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)phenoxy)propylphosphonic acid

Guidance literature:: With water; trifluoroacetic acid; In acetonitrile;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1292305-62-4
3-(2-(4-hydroxy-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)phenoxy)propylphosphonic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / diethyl ether / 20 °C / Reflux

1.2: 1.5 h / 20 °C

2.1: hydrogen / 20% palladium hydroxide on activated carbon / methanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / -50 - 23 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: trifluoroacetic acid; water / acetonitrile

With n-butyllithium; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 20% palladium hydroxide on activated carbon; In methanol; diethyl ether; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 95-56-7
2-hydroxybromobenzene

: 1292305-62-4
3-(2-(4-hydroxy-1-((2R,3S)-2-propyl-1-(3-(trifluoromethyl)picolinoyl)-3-(5-(trifluoromethyl)thiophen-3-yloxy)piperidine-3-carbonyl)piperidin-4-yl)phenoxy)propylphosphonic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / diethyl ether / 20 °C / Reflux

1.2: 1.5 h / 20 °C

2.1: hydrogen / 20% palladium hydroxide on activated carbon / methanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / -50 - 23 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: trifluoroacetic acid; water / acetonitrile

With n-butyllithium; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 20% palladium hydroxide on activated carbon; In methanol; diethyl ether; N,N-dimethyl-formamide; acetonitrile;