methyl 4-{2-[2-{3-[(benzylsulfonyl)amino]propyl}-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

Base Information

Chemical Name:methyl 4-{2-[2-{3-[(benzylsulfonyl)amino]propyl}-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate
CAS No.:540524-76-3
Molecular Formula:C₄₁H₃₉ClN₂O₅S
Molecular Weight:707.29
Hs Code.:

Synonyms:methyl 4-{2-[2-{3-[(benzylsulfonyl)amino]propyl}-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

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Chemical Property of methyl 4-{2-[2-{3-[(benzylsulfonyl)amino]propyl}-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

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Technology Process of methyl 4-{2-[2-{3-[(benzylsulfonyl)amino]propyl}-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

There total 9 articles about methyl 4-{2-[2-{3-[(benzylsulfonyl)amino]propyl}-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 540524-75-2
methyl 4-{2-[2-(3-bromopropyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

: 1939-99-7
benzenesulfonyl chloride

: 540524-76-3
methyl 4-{2-[2-{3-[(benzylsulfonyl)amino]propyl}-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

Guidance literature:: benzenesulfonyl chloride; With sodium hydride; In N,N-dimethyl-formamide; for 0.5h;

methyl 4-{2-[2-(3-bromopropyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate; In N,N-dimethyl-formamide; for 1h;

Reference yield: 17.0%

: 540524-75-2
methyl 4-{2-[2-(3-bromopropyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

: 4563-33-1
phenyl-methanesulfonic acid amide

: 540524-76-3
methyl 4-{2-[2-{3-[(benzylsulfonyl)amino]propyl}-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

Guidance literature:: phenyl-methanesulfonic acid amide; With sodium hydride; In N,N-dimethyl-formamide; for 0.5h;

methyl 4-{2-[2-(3-bromopropyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate; In N,N-dimethyl-formamide; for 1h; Further stages.;
DOI:10.1021/jm061131z

Reference yield:

: 479422-24-7
methyl 4-[2-[5-chloro-(1-diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]benzoate

: 540524-76-3
methyl 4-{2-[2-{3-[(benzylsulfonyl)amino]propyl}-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: NBS; benzoyl peroxide / CCl₄ / 2.5 h / Heating

2.1: 0.750 g / Ag₂CO₃; H₂O / acetone

3.1: 91 percent / tetrahydrofuran / 1 h

4.1: 97 percent / morpholine / Pd(PPh₃)4 / tetrahydrofuran / 4 h

5.1: 79 percent / H₂ / Pt/C / methanol / 24 h / 760.05 Torr

6.1: (COCl)2 / CH₂Cl₂ / 1 h

6.2: 83 percent / Zn(BH₄)2; TMEDA / diethyl ether / 0.25 h

7.1: 86 percent / CBr₄; PS-PPh₃ / CH₂Cl₂ / 2 h

8.1: NaH / dimethylformamide / 0.5 h

8.2: 17 percent / dimethylformamide / 1 h

With morpholine; N-Bromosuccinimide; oxalyl dichloride; PS-PPh₃; carbon tetrabromide; water; hydrogen; sodium hydride; silver carbonate; dibenzoyl peroxide; platinum on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm061131z