Acetic acid 2-[4-(diethoxy-phosphorylmethyl)-phenyl]-benzothiazol-7-yl ester

Base Information

Chemical Name:Acetic acid 2-[4-(diethoxy-phosphorylmethyl)-phenyl]-benzothiazol-7-yl ester
CAS No.:101078-68-6
Molecular Formula:C₂₀H₂₂NO₅PS
Molecular Weight:419.438
Hs Code.:

Synonyms:Acetic acid 2-[4-(diethoxy-phosphorylmethyl)-phenyl]-benzothiazol-7-yl ester

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Chemical Property of Acetic acid 2-[4-(diethoxy-phosphorylmethyl)-phenyl]-benzothiazol-7-yl ester

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Technology Process of Acetic acid 2-[4-(diethoxy-phosphorylmethyl)-phenyl]-benzothiazol-7-yl ester

There total 9 articles about Acetic acid 2-[4-(diethoxy-phosphorylmethyl)-phenyl]-benzothiazol-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: Acetic acid 2-(4-bromomethyl-phenyl)-benzothiazol-7-yl ester

: 122-52-1
triethyl phosphite

: 101078-68-6
Acetic acid 2-[4-(diethoxy-phosphorylmethyl)-phenyl]-benzothiazol-7-yl ester

Guidance literature:: at 130 - 160 ℃; for 0.25h;
DOI:10.1021/jm00155a037

Reference yield:

: 99-94-5
p-Toluic acid

: 101078-68-6
Acetic acid 2-[4-(diethoxy-phosphorylmethyl)-phenyl]-benzothiazol-7-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1: SOCl₂, DMF / 1.5 h / Heating

2: pyridine / tetrahydrofuran / 1 h / Ambient temperature

3: 92 percent / 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (Lawesson's reagent) / toluene / 1 h / Heating

4: 46 percent / K₃Fe(CN)6, KOH / H₂O / 3 h / Ambient temperature

5: 96 percent / conc. aq. HBr / 6 h / Heating

6: 100 percent / 3 h / Heating

7: N-bromosuccinimide, benzoyl peroxide / CCl₄ / 12 h / Heating

8: 77 percent / 0.25 h / 130 - 160 °C

With Lawessons reagent; pyridine; potassium hydroxide; N-Bromosuccinimide; thionyl chloride; Perbenzoic acid; hydrogen bromide; N,N-dimethyl-formamide; potassium hexacyanoferrate(III); In tetrahydrofuran; tetrachloromethane; water; toluene;
DOI:10.1021/jm00155a037

Reference yield:

: 33667-89-9
N-(4-chlorophenyl)-4-methylbenzamide

: 101078-68-6
Acetic acid 2-[4-(diethoxy-phosphorylmethyl)-phenyl]-benzothiazol-7-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 67 percent / P₂S₅ / benzene

2: 46 percent / K₃Fe(CN)6, KOH / H₂O / 3 h / Ambient temperature

3: 96 percent / conc. aq. HBr / 6 h / Heating

4: 100 percent / 3 h / Heating

5: N-bromosuccinimide, benzoyl peroxide / CCl₄ / 12 h / Heating

6: 77 percent / 0.25 h / 130 - 160 °C

With potassium hydroxide; N-Bromosuccinimide; Perbenzoic acid; tetraphosphorus decasulfide; hydrogen bromide; potassium hexacyanoferrate(III); In tetrachloromethane; water; benzene;
DOI:10.1021/jm00155a037