N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Base Information

Chemical Name:N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide
CAS No.:1228465-54-0
Molecular Formula:C₂₅H₂₀F₄N₆O₂S
Molecular Weight:544.532
Hs Code.:

Synonyms:N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Suppliers and Price of N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

There total 13 articles about N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1125632-85-0
N-{5-[(3-amino-4-fluorophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropane carboxamide

: 1548-13-6
p-trifluoromethyl-phenylisocyanate

: 1228465-54-0
N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 332370-72-6
N-(tert-butoxycarbonyl)-4-fluoro-3-nitroaniline

: 1228465-54-0
N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr

3.1: tetrahydrofuran / 18 h / 4 - 10 °C

4.1: trifluoroacetic acid / 2 h / 4 - 10 °C

5.1: N,N-dimethyl-formamide / 22 h / 140 °C

6.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 14 h / 20 °C / 760.05 Torr

7.1: acetic acid / 0.17 h / 20 °C

7.2: 0.17 h / 20 °C

8.1: bromine; acetic acid / 20 h / 20 °C

9.1: pyridine / 1 h / 4 - 20 °C

10.1: ethanol; sodium tetrahydroborate; methanol / 0.5 h / 4 °C

10.2: 0.08 h / 20 °C

11.1: N,N-dimethyl-formamide / 12 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; ethanol; hydrogen; bromine; caesium carbonate; acetic acid; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 1228465-54-0
N-(5-{[4-fluoro-3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide / 22 h / 140 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 14 h / 20 °C / 760.05 Torr

3.1: acetic acid / 0.17 h / 20 °C

3.2: 0.17 h / 20 °C

4.1: bromine; acetic acid / 20 h / 20 °C

5.1: pyridine / 1 h / 4 - 20 °C

6.1: ethanol; sodium tetrahydroborate; methanol / 0.5 h / 4 °C

6.2: 0.08 h / 20 °C

7.1: N,N-dimethyl-formamide / 12 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; ethanol; hydrogen; bromine; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;