4-fluorophenylephrine

Base Information

Chemical Name:4-fluorophenylephrine
CAS No.:103439-06-1
Molecular Formula:C₉H₁₂FNO₂
Molecular Weight:185.198
Hs Code.:

Synonyms:4-fluorophenylephrine

Suppliers and Price of 4-fluorophenylephrine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-fluorophenylephrine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 4-fluorophenylephrine

There total 7 articles about 4-fluorophenylephrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 103438-99-9
1-(3-Benzyloxy-4-fluoro-phenyl)-2-methylamino-ethanol

: 103439-06-1
4-fluorophenylephrine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 4h;
DOI:10.1021/jm00160a030

Reference yield:

: 103438-85-3
4-fluoro-3-hydroxybenzaldehyde

: 103439-06-1
4-fluorophenylephrine

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / K₂CO₃ / acetone / Ambient temperature

2: 1.) ZnI₂, 2.) LiAlH₄ / 1.) overnight, 2.) ether, reflux, 3 h

3: 57 percent / 6 h / Heating

4: 70 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

5: 77 percent / H₂ / Pd/C / ethanol / 4 h

With lithium aluminium tetrahydride; hydrogen; potassium carbonate; zinc(II) iodide; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetone;
DOI:10.1021/jm00160a030

Reference yield:

: 5-Dimethoxymethyl-2-fluoro-phenylamine

: 103439-06-1
4-fluorophenylephrine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) sodium nitrite, H₂SO₄, 2.) Cu(NO₃)2, Cu₂O / 1.) H₂O, 0-5 deg C, 5 min, 2.) H₂O

2: 74 percent / K₂CO₃ / acetone / Ambient temperature

3: 1.) ZnI₂, 2.) LiAlH₄ / 1.) overnight, 2.) ether, reflux, 3 h

4: 57 percent / 6 h / Heating

5: 70 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

6: 77 percent / H₂ / Pd/C / ethanol / 4 h

With copper(I) oxide; lithium aluminium tetrahydride; sulfuric acid; hydrogen; potassium carbonate; copper(II) nitrate; zinc(II) iodide; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetone;
DOI:10.1021/jm00160a030