(2S,3R)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-(4-methoxyphenyl)-2-methylpiperidine

Base Information

Chemical Name:(2S,3R)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-(4-methoxyphenyl)-2-methylpiperidine
CAS No.:450416-84-9
Molecular Formula:C₂₁H₂₇NO₂
Molecular Weight:325.451
Hs Code.:

Synonyms:(2S,3R)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-(4-methoxyphenyl)-2-methylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-(4-methoxyphenyl)-2-methylpiperidine

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Technology Process of (2S,3R)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-(4-methoxyphenyl)-2-methylpiperidine

There total 4 articles about (2S,3R)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-(4-methoxyphenyl)-2-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 430461-97-5
(3R,8R,8aR)-8-(4-methoxyphenyl)-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: 450416-84-9
(2S,3R)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-(4-methoxyphenyl)-2-methylpiperidine

Guidance literature:: With lithium aluminium tetrahydride; aluminium trichloride; In tetrahydrofuran; at -78 - 20 ℃; for 3.5h;
DOI:10.1021/jo025894f

Reference yield:

: 122-84-9
4-methoxybenzyl methyl ketone

: 450416-84-9
(2S,3R)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-(4-methoxyphenyl)-2-methylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / NaH

2: 15 percent / p-TsOH / toluene / 14 h / Heating

3: 87 percent / LiAlH₄; AlCl₃ / tetrahydrofuran / 3.5 h / -78 - 20 °C

With lithium aluminium tetrahydride; aluminium trichloride; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; toluene;
DOI:10.1021/jo025894f

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 450416-84-9
(2S,3R)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-(4-methoxyphenyl)-2-methylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 15 percent / p-TsOH / toluene / 14 h / Heating

2: 87 percent / LiAlH₄; AlCl₃ / tetrahydrofuran / 3.5 h / -78 - 20 °C

With lithium aluminium tetrahydride; aluminium trichloride; toluene-4-sulfonic acid; In tetrahydrofuran; toluene;
DOI:10.1021/jo025894f