(R)-BoroPhg(+)-Pinanediol-HCl

Base Information

Chemical Name:(R)-BoroPhg(+)-Pinanediol-HCl
CAS No.:476334-31-3
Molecular Formula:C₁₇H₂₄BNO₂*ClH
Molecular Weight:321.655
Hs Code.:
Mol file:476334-31-3.mol

Synonyms:4,6-Methano-1,3,2-benzodioxaborole-2-methanamine,hexahydro-3a,5,5-trimethyl-a-phenyl-, hydrochloride, (aR,3aS,4S,6S,7aR)- (9CI)

Suppliers and Price of (R)-BoroPhg(+)-Pinanediol-HCl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 10 raw suppliers

Chemical Property of (R)-BoroPhg(+)-Pinanediol-HCl

Chemical Property:

PSA：44.48000
LogP:4.55170

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-BoroPhg(+)-Pinanediol-HCl

There total 3 articles about (R)-BoroPhg(+)-Pinanediol-HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: phenylboronic acid (1R,2R,3S,5R)-(-)-2,3-pinanediol ester

: 476334-31-3
(S)-(1-amino-1-phenylmethyl)boronic acid (1R,2R,3S,5R)-(-)-2,3-pinanediol ester hydrochloride salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -100 °C / Inert atmosphere

1.2: 0.58 h / -100 °C / Inert atmosphere

1.3: -100 - 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2.2: 3 h / -60 - 20 °C / Inert atmosphere

With n-butyllithium; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; 1.1: |Matteson Homologation / 1.2: |Matteson Homologation / 1.3: |Matteson Homologation;
DOI:10.1021/acs.jmedchem.9b00735

Reference yield:

: 22422-34-0
(1R,2R,3S,5R)-2,3-pinane diol

: 476334-31-3
(S)-(1-amino-1-phenylmethyl)boronic acid (1R,2R,3S,5R)-(-)-2,3-pinanediol ester hydrochloride salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethyl ether / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.67 h / -100 °C / Inert atmosphere

2.2: 0.58 h / -100 °C / Inert atmosphere

2.3: -100 - 20 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

3.2: 3 h / -60 - 20 °C / Inert atmosphere

With n-butyllithium; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; hexane; 2.1: |Matteson Homologation / 2.2: |Matteson Homologation / 2.3: |Matteson Homologation;
DOI:10.1021/acs.jmedchem.9b00735

Reference yield:

: 476334-31-3
(S)-(1-amino-1-phenylmethyl)boronic acid (1R,2R,3S,5R)-(-)-2,3-pinanediol ester hydrochloride salt

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃;

With hydrogenchloride; In 1,4-dioxane; diethyl ether; at -60 ℃; for 3h;