2-(benzo[b]thiophene-2-carboxamido)-4-(4-carbamimidoylphenylcarbamoyl)benzoic acidtrifluoroacetic acid

Base Information

• Chemical Name: 2-(benzo[b]thiophene-2-carboxamido)-4-(4-carbamimidoylphenylcarbamoyl)benzoic acidtrifluoroacetic acid
• CAS No.: 1374778-10-5
• Molecular Formula: C₂HF₃O₂*C₂₄H₁₈N₄O₄S
• Molecular Weight: 572.521

Synonyms:2-(benzo[b]thiophene-2-carboxamido)-4-(4-carbamimidoylphenylcarbamoyl)benzoic acidtrifluoroacetic acid

Chemical Property of 2-(benzo[b]thiophene-2-carboxamido)-4-(4-carbamimidoylphenylcarbamoyl)benzoic acidtrifluoroacetic acid

Chemical Property:

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Technology Process of 2-(benzo[b]thiophene-2-carboxamido)-4-(4-carbamimidoylphenylcarbamoyl)benzoic acidtrifluoroacetic acid

There total 6 articles about 2-(benzo[b]thiophene-2-carboxamido)-4-(4-carbamimidoylphenylcarbamoyl)benzoic acidtrifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H18N4O5S (1374779-48-2) → 2-(benzo[b]thiophene-2-carboxamido)-4-(4-carbamimidoylphenylcarbamoyl)benzoic acidtrifluoroacetic acid (1374778-10-5)

Guidance literature:

C₂₄H₁₈N₄O₅S; With trifluoroacetic anhydride; In dichloromethane; at 20 ℃; for 2h;

With hydrogen; trifluoroacetic acid; palladium on activated charcoal;

Reference yield:

1-methyl-2-aminoterephthalate (60728-41-8) → 2-(benzo[b]thiophene-2-carboxamido)-4-(4-carbamimidoylphenylcarbamoyl)benzoic acidtrifluoroacetic acid (1374778-10-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 14 h / Reflux

2.1: oxalyl dichloride / dichloromethane / 2 h / 20 °C

2.2: 16 h / 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

4.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol / 48 h / Reflux

5.1: trifluoroacetic anhydride / dichloromethane / 2 h / 20 °C

With oxalyl dichloride; hydroxylamine hydrochloride; water; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

benzothiophene-2-carboxylic acid chloride (39827-11-7) → 2-(benzo[b]thiophene-2-carboxamido)-4-(4-carbamimidoylphenylcarbamoyl)benzoic acidtrifluoroacetic acid (1374778-10-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 14 h / Reflux

2.1: oxalyl dichloride / dichloromethane / 2 h / 20 °C

2.2: 16 h / 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

4.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol / 48 h / Reflux

5.1: trifluoroacetic anhydride / dichloromethane / 2 h / 20 °C

With oxalyl dichloride; hydroxylamine hydrochloride; water; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

benzothiophene-2-carboxylic acid chloride

1-methyl-2-aminoterephthalate

C₁₈H₁₃NO₅S

C₂₅H₁₇N₃O₄S

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