(Z)-3-(4-(trifluoromethyl)benzyl)-5-(4-aminobenzylidene)thiazolidine-2,4-dione

Base Information

Chemical Name:(Z)-3-(4-(trifluoromethyl)benzyl)-5-(4-aminobenzylidene)thiazolidine-2,4-dione
CAS No.:1442655-25-5
Molecular Formula:C₁₈H₁₃F₃N₂O₂S
Molecular Weight:378.375
Hs Code.:

Synonyms:(Z)-3-(4-(trifluoromethyl)benzyl)-5-(4-aminobenzylidene)thiazolidine-2,4-dione

Suppliers and Price of (Z)-3-(4-(trifluoromethyl)benzyl)-5-(4-aminobenzylidene)thiazolidine-2,4-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-3-(4-(trifluoromethyl)benzyl)-5-(4-aminobenzylidene)thiazolidine-2,4-dione

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Technology Process of (Z)-3-(4-(trifluoromethyl)benzyl)-5-(4-aminobenzylidene)thiazolidine-2,4-dione

There total 3 articles about (Z)-3-(4-(trifluoromethyl)benzyl)-5-(4-aminobenzylidene)thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1442655-06-2
(Z)-3-(4-(trifluoromethyl)benzyl)-5-(4-nitrobenzylidene)thiazolidine-2,4-dione

: 1442655-25-5
(Z)-3-(4-(trifluoromethyl)benzyl)-5-(4-aminobenzylidene)thiazolidine-2,4-dione

Guidance literature:: With hydrogenchloride; iron; In ethanol; water; for 2h; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2013.02.030

Reference yield:

: 177703-41-2
5-(4-nitro-benzylidene)-thiazolidine-2,4-dione

: 1442655-25-5
(Z)-3-(4-(trifluoromethyl)benzyl)-5-(4-aminobenzylidene)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

1.2: 4-trifluoromethylbenzyl halide / 2 h / 0 - 20 °C / Inert atmosphere

2.1: iron; hydrogenchloride / ethanol; water / 2 h / Inert atmosphere; Reflux

With hydrogenchloride; iron; sodium hydride; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.02.030

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 1442655-25-5
(Z)-3-(4-(trifluoromethyl)benzyl)-5-(4-aminobenzylidene)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

2.2: 4-trifluoromethylbenzyl halide / 2 h / 0 - 20 °C / Inert atmosphere

3.1: iron; hydrogenchloride / ethanol; water / 2 h / Inert atmosphere; Reflux

With hydrogenchloride; iron; sodium hydride; In ethanol; water; N,N-dimethyl-formamide; 1.1: |Knoevenagel Condensation;
DOI:10.1016/j.ejmech.2013.02.030