3-[{3-[[5-(tert-butyldimethylsilanyloxy)pentyl](2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]butyric acid

Base Information

Chemical Name:3-[{3-[[5-(tert-butyldimethylsilanyloxy)pentyl](2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]butyric acid
CAS No.:474886-90-3
Molecular Formula:C₃₀H₄₆N₄O₁₁S₂Si
Molecular Weight:730.933
Hs Code.:

Synonyms:3-[{3-[[5-(tert-butyldimethylsilanyloxy)pentyl](2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]butyric acid

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Chemical Property of 3-[{3-[[5-(tert-butyldimethylsilanyloxy)pentyl](2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]butyric acid

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Technology Process of 3-[{3-[[5-(tert-butyldimethylsilanyloxy)pentyl](2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]butyric acid

There total 5 articles about 3-[{3-[[5-(tert-butyldimethylsilanyloxy)pentyl](2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 474886-90-3
3-[{3-[[5-(tert-butyldimethylsilanyloxy)pentyl](2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / triethylamine / CH₂Cl₂ / 0.5 h / 20 °C

2: 49 percent / Ph₃P; DEAD / toluene / 0.17 h / 20 °C

3: 86 percent / pyrrolidine / Pd(PPh₃)4 / CH₂Cl₂ / 0.5 h / 20 °C

With pyrrolidine; triethylamine; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; toluene; 2: Mitsunobu reaction;
DOI:10.1016/S0040-4020(02)00626-9

Reference yield:

: 196214-23-0
N-(3-hydroxypropyl)-2-nitrobenzenesulfonamide

: 474886-90-3
3-[{3-[[5-(tert-butyldimethylsilanyloxy)pentyl](2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / cesium carbonate / acetonitrile / 15 h / 60 °C

2: 49 percent / Ph₃P; DEAD / toluene / 0.17 h / 20 °C

3: 86 percent / pyrrolidine / Pd(PPh₃)4 / CH₂Cl₂ / 0.5 h / 20 °C

With pyrrolidine; caesium carbonate; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; toluene; acetonitrile; 2: Mitsunobu reaction;
DOI:10.1016/S0040-4020(02)00626-9

Reference yield:

: 318466-82-9
3-(2-nitrobenzenesulfonylamino)butyric acid allyl ester

: 474886-90-3
3-[{3-[[5-(tert-butyldimethylsilanyloxy)pentyl](2-nitrobenzenesulfonyl)amino]propyl}(2-nitrobenzenesulfonyl)amino]butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 49 percent / Ph₃P; DEAD / toluene / 0.17 h / 20 °C

2: 86 percent / pyrrolidine / Pd(PPh₃)4 / CH₂Cl₂ / 0.5 h / 20 °C

With pyrrolidine; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; toluene; 1: Mitsunobu reaction;
DOI:10.1016/S0040-4020(02)00626-9