C₂₄H₃₇⁽¹⁸⁾FN₂O₈

Base Information

• Chemical Name: C₂₄H₃₇⁽¹⁸⁾FN₂O₈
• CAS No.: 1262523-98-7
• Molecular Formula: C₂₄H₃₇FN₂O₈
• Molecular Weight: 499.566
• Mol file: 1262523-98-7.mol

Synonyms:C₂₄H₃₇⁽¹⁸⁾FN₂O₈

Chemical Property of C₂₄H₃₇⁽¹⁸⁾FN₂O₈

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of C₂₄H₃₇⁽¹⁸⁾FN₂O₈

There total 12 articles about C₂₄H₃₇⁽¹⁸⁾FN₂O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,4S)‐tert‐butyl 2‐(tert‐butoxycarbonylamino)‐5‐oxo‐4‐(tosyloxy)‐5‐(2,4,6‐trimethoxybenzylamino)pentanoate (1262523-66-9) → C24H37(18)FN2O8 (1262523-98-7)

Guidance literature:

With 18-crown-6 ether; potassium hydrogencarbonate; [18F]fluoride ion, cyclotron produced, NCA; In acetonitrile; at 90 ℃; for 0.25h; Inert atmosphere; Flow reactor;

DOI:10.1002/jlcr.3719

Reference yield:

(2R,4R)-tert-butyl-2-(tert-butoxycarbonylamino)-5-oxo-4-(tosyloxy)-5-(2,4,6-trimethoxybenzylamino)pentanoate (1262523-83-0) → C24H37(18)FN2O8 (1262523-98-7)

Guidance literature:

With [¹⁸F]-potassium fluoride; potassium carbonate; In acetonitrile; at 70 ℃; for 0.333333h;

DOI:10.1021/ja109203d

Reference yield:

2-(isocyanomethyl)-1,3,5-trimethoxybenzene (480438-26-4) → C24H37(18)FN2O8 (1262523-98-7)

Guidance literature:

Multi-step reaction with 4 steps

1: dichloromethane / 24 h / 20 °C

2: sodium hydrogencarbonate; thiourea / tetrahydrofuran; water / 1.5 h / 50 °C

3: triethylamine

4: [¹⁸F]-potassium fluoride; potassium carbonate / acetonitrile / 0.33 h / 70 °C

With [¹⁸F]-potassium fluoride; sodium hydrogencarbonate; potassium carbonate; triethylamine; thiourea; In tetrahydrofuran; dichloromethane; water; acetonitrile; 1: Passerini reaction;

DOI:10.1021/ja109203d

upstream raw materials:

tert-butyl (S)-2-((tert-butoxycarbonyl)amino)-4-oxobutanoate

2-(isocyanomethyl)-1,3,5-trimethoxybenzene

C₂₆H₃₉ClN₂O₁₀

C₂₄H₃₈N₂O₉