1-(4-benzoylbicyclo[2.2.2]octyl)-4-(4-(α-naphthyl)bicyclo[2.2.2]octyl)benzene 1,2-ethanediyl ketal

Base Information

Chemical Name:1-(4-benzoylbicyclo[2.2.2]octyl)-4-(4-(α-naphthyl)bicyclo[2.2.2]octyl)benzene 1,2-ethanediyl ketal
CAS No.:313342-09-5
Molecular Formula:C₄₁H₄₄O₂
Molecular Weight:568.799
Hs Code.:

Synonyms:1-(4-benzoylbicyclo[2.2.2]octyl)-4-(4-(α-naphthyl)bicyclo[2.2.2]octyl)benzene 1,2-ethanediyl ketal

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Chemical Property of 1-(4-benzoylbicyclo[2.2.2]octyl)-4-(4-(α-naphthyl)bicyclo[2.2.2]octyl)benzene 1,2-ethanediyl ketal

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Technology Process of 1-(4-benzoylbicyclo[2.2.2]octyl)-4-(4-(α-naphthyl)bicyclo[2.2.2]octyl)benzene 1,2-ethanediyl ketal

There total 13 articles about 1-(4-benzoylbicyclo[2.2.2]octyl)-4-(4-(α-naphthyl)bicyclo[2.2.2]octyl)benzene 1,2-ethanediyl ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 313342-05-1
4-benzoyl-1-iodobicyclo[2.2.2]octane 1,2-ethanediyl ketal

: 313341-98-9
4-(4-(α-naphthyl)bicyclo[2.2.2]octyl)cyclohex-2-enone

: 313342-09-5
1-(4-benzoylbicyclo[2.2.2]octyl)-4-(4-(α-naphthyl)bicyclo[2.2.2]octyl)benzene 1,2-ethanediyl ketal

Guidance literature:: 4-benzoyl-1-iodobicyclo[2.2.2]octane 1,2-ethanediyl ketal; With tert.-butyl lithium; In diethyl ether; pentane; at -70 - -50 ℃; for 0.5h;

4-(4-(α-naphthyl)bicyclo[2.2.2]octyl)cyclohex-2-enone; In diethyl ether; pentane; at -70 - 20 ℃; Further stages.;
DOI:10.1021/jo0003145

Reference yield:

: 74467-18-8
4-Iodo-1-bicyclo<2.2.2>octyl Methyl Ether

: 313342-09-5
1-(4-benzoylbicyclo[2.2.2]octyl)-4-(4-(α-naphthyl)bicyclo[2.2.2]octyl)benzene 1,2-ethanediyl ketal

Guidance literature:: Multi-step reaction with 4 steps

1.1: tert-butyllithium / diethyl ether; pentane / 0.75 h / -70 °C

1.2: 59 percent / diethyl ether; pentane / -70 - 20 °C

2.1: 71 percent / HI / H₂O / Heating

3.1: 92 percent / p-toluenesulfonic acid / benzene / 4.5 h / Heating

4.1: tert-butyllithium / diethyl ether; pentane / 0.5 h / -70 - -50 °C

4.2: 32 percent / diethyl ether; pentane / -70 - 20 °C

With hydrogen iodide; tert.-butyl lithium; toluene-4-sulfonic acid; In diethyl ether; water; pentane; benzene; 1.1: Metallation / 1.2: Acylation / 2.1: Substitution / 3.1: cyclocondensation / 4.1: Metallation / 4.2: Addition;
DOI:10.1021/jo0003145

Reference yield:

: 93-58-3,5705-52-2,80226-58-0
benzoic acid methyl ester

: 313342-09-5
1-(4-benzoylbicyclo[2.2.2]octyl)-4-(4-(α-naphthyl)bicyclo[2.2.2]octyl)benzene 1,2-ethanediyl ketal

Guidance literature:: Multi-step reaction with 4 steps

1.1: tert-butyllithium / diethyl ether; pentane / 0.75 h / -70 °C

1.2: 59 percent / diethyl ether; pentane / -70 - 20 °C

2.1: 71 percent / HI / H₂O / Heating

3.1: 92 percent / p-toluenesulfonic acid / benzene / 4.5 h / Heating

4.1: tert-butyllithium / diethyl ether; pentane / 0.5 h / -70 - -50 °C

4.2: 32 percent / diethyl ether; pentane / -70 - 20 °C

With hydrogen iodide; tert.-butyl lithium; toluene-4-sulfonic acid; In diethyl ether; water; pentane; benzene; 1.1: Metallation / 1.2: Acylation / 2.1: Substitution / 3.1: cyclocondensation / 4.1: Metallation / 4.2: Addition;
DOI:10.1021/jo0003145