tert-butyl (3S)-3-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl (3S)-3-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate
• CAS No.: 1353993-49-3
• Molecular Formula: C₁₇H₂₅NO₅S
• Molecular Weight: 355.455
• Mol file: 1353993-49-3.mol

Synonyms:tert-butyl (3S)-3-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate

Chemical Property of tert-butyl (3S)-3-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

99.3% ^*data from raw suppliers

(S)-tert-Butyl3-(tosyloxy)piperidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of tert-butyl (3S)-3-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate

There total 2 articles about tert-butyl (3S)-3-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

p-toluenesulfonyl chloride (98-59-9) + tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate (143900-44-1) → tert-butyl (3S)-3-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate (1353993-49-3,85275-46-3)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield:

→ tert-butyl (3S)-3-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate (1353993-49-3,85275-46-3)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 24h;

Reference yield: 30.0%

5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (330792-70-6) + tert-butyl (3S)-3-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate (1353993-49-3,85275-46-3) → (R)-tert-butyl 3-(5-amino-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate (1612774-50-1)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 5h;

upstream raw materials:

p-toluenesulfonyl chloride

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Downstream raw materials:

tert-butyl (R)-3-(4-amino-3-(4-aminophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

tert-butyl (3R)-3-[4-amino-3-[4-(3-fluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

3-[4-(3-fluorophenoxy)phenyl]-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

tert-butyl (3R)-3-[4-amino-3-[4-(2,6-difluorophenoxy)-phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

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