(R)-(3-methyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)butyl)boronic acid

Base Information

Chemical Name:(R)-(3-methyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)butyl)boronic acid
CAS No.:1613134-34-1
Molecular Formula:C₂₀H₃₀BN₅O₇
Molecular Weight:463.298
Hs Code.:

Synonyms:(R)-(3-methyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)butyl)boronic acid

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Chemical Property of (R)-(3-methyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)butyl)boronic acid

Chemical Property:

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Technology Process of (R)-(3-methyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)butyl)boronic acid

There total 4 articles about (R)-(3-methyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)butyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1613134-42-1
N-[(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decan-4-yl]butyl]-1-{2-[(2,3,4-trimethoxyphenyl)formamido]ethyl}-1H-1,2,3-triazole-4-carboxamide

: 1613134-34-1
(R)-(3-methyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)butyl)boronic acid

Guidance literature:: With hydrogenchloride; Dihydroxy-isobutyl-boran; In methanol; n-heptane; water; at 20 ℃;

Reference yield:

: 1613134-41-0
1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid

: 1613134-34-1
(R)-(3-methyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)butyl)boronic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 3.25 h / 0 - 20 °C

2: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; n-heptane; water / 20 °C

With hydrogenchloride; Dihydroxy-isobutyl-boran; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; n-heptane; dichloromethane; water;

Reference yield:

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 1613134-34-1
(R)-(3-methyl-1-(1-(2-(2,3,4-trimethoxybenzamido)ethyl)-1H-1,2,3-triazole-4-carboxamido)butyl)boronic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 1 h / 0 °C

1.2: 20 °C

2.1: sodium hydroxide / methanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 3.25 h / 0 - 20 °C

4.1: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; n-heptane; water / 20 °C

With hydrogenchloride; Dihydroxy-isobutyl-boran; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In methanol; n-heptane; dichloromethane; N,N-dimethyl acetamide; water;