(S)-6-[4-[2-[3-(indol-4-yloxy)-2-hydroxypropylamino]-2-methylpropyl]phenoxy]-3-cyanopyridine

Base Information

Chemical Name:(S)-6-[4-[2-[3-(indol-4-yloxy)-2-hydroxypropylamino]-2-methylpropyl]phenoxy]-3-cyanopyridine
CAS No.:189119-09-3
Molecular Formula:C₂₇H₂₈N₄O₃
Molecular Weight:456.544
Hs Code.:

Synonyms:(S)-6-[4-[2-[3-(indol-4-yloxy)-2-hydroxypropylamino]-2-methylpropyl]phenoxy]-3-cyanopyridine

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Chemical Property of (S)-6-[4-[2-[3-(indol-4-yloxy)-2-hydroxypropylamino]-2-methylpropyl]phenoxy]-3-cyanopyridine

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Technology Process of (S)-6-[4-[2-[3-(indol-4-yloxy)-2-hydroxypropylamino]-2-methylpropyl]phenoxy]-3-cyanopyridine

There total 4 articles about (S)-6-[4-[2-[3-(indol-4-yloxy)-2-hydroxypropylamino]-2-methylpropyl]phenoxy]-3-cyanopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 189119-39-9
2-(4-(2-amino-2-methylpropyl)phenoxy)-5-carbonitrilepyridine

: 70260-86-5
4-(S)-oxiranylmethoxy-1H-indole

: 189119-09-3
(S)-6-[4-[2-[3-(indol-4-yloxy)-2-hydroxypropylamino]-2-methylpropyl]phenoxy]-3-cyanopyridine

Guidance literature:: In isopropyl alcohol; at 75 - 80 ℃; for 18h;
DOI:10.1002/jlcr.1086

Reference yield:

: 937193-79-8
6-(4-(2-amino-2-methylpropyl)phenoxy)-3-iodopyridine

: 189119-09-3
(S)-6-[4-[2-[3-(indol-4-yloxy)-2-hydroxypropylamino]-2-methylpropyl]phenoxy]-3-cyanopyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / copper(I) iodide; 1-methyl-2-pyrrolidinone / 4.5 h / 190 - 200 °C

2: 68 percent / propan-2-ol / 18 h / 75 - 80 °C

With 1-methyl-pyrrolidin-2-one; copper(l) iodide; In isopropyl alcohol;
DOI:10.1002/jlcr.1086

Reference yield:

: 73290-22-9
2-bromo-5-iodo-pyridine

: 189119-09-3
(S)-6-[4-[2-[3-(indol-4-yloxy)-2-hydroxypropylamino]-2-methylpropyl]phenoxy]-3-cyanopyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / potassium carbonate / dimethylformamide / 20.5 h / 140 - 155 °C

2: 93 percent / copper(I) iodide; 1-methyl-2-pyrrolidinone / 4.5 h / 190 - 200 °C

3: 68 percent / propan-2-ol / 18 h / 75 - 80 °C

With 1-methyl-pyrrolidin-2-one; copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1002/jlcr.1086