tert-butyl 2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-2-(4-((4'-(dimethylamino)phenyl)diazenyl)phenyl)acetamido)acetate

Base Information

• Chemical Name: tert-butyl 2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-2-(4-((4'-(dimethylamino)phenyl)diazenyl)phenyl)acetamido)acetate
• CAS No.: 1337956-60-1
• Molecular Formula: C₃₉H₄₃N₅O₅
• Molecular Weight: 661.801
• Mol file: 1337956-60-1.mol

Synonyms:tert-butyl 2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-2-(4-((4'-(dimethylamino)phenyl)diazenyl)phenyl)acetamido)acetate

Chemical Property of tert-butyl 2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-2-(4-((4'-(dimethylamino)phenyl)diazenyl)phenyl)acetamido)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-2-(4-((4'-(dimethylamino)phenyl)diazenyl)phenyl)acetamido)acetate

There total 2 articles about tert-butyl 2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-2-(4-((4'-(dimethylamino)phenyl)diazenyl)phenyl)acetamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-(4-((4'-(dimethylamino)phenyl)diazenyl)phenyl)acetic acid (103041-67-4) + tert-butyl N-(2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}ethyl)glycinate (169396-89-8) → tert-butyl 2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-2-(4-((4'-(dimethylamino)phenyl)diazenyl)phenyl)acetamido)acetate (1337956-60-1)

Guidance literature:

2-(4-((4'-(dimethylamino)phenyl)diazenyl)phenyl)acetic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 1.25h;

tert-butyl N-(2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}ethyl)glycinate; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 36h;

DOI:10.1080/15257770.2011.604661

Reference yield:

4-aminophenylacetic acid (1197-55-3) → tert-butyl 2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-2-(4-((4'-(dimethylamino)phenyl)diazenyl)phenyl)acetamido)acetate (1337956-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / Cooling

1.2: 3 h

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 1.25 h

2.2: 36 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium nitrite; In water; N,N-dimethyl-formamide;

DOI:10.1080/15257770.2011.604661

Reference yield: 91.0%

tert-butyl 2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-2-(4-((4'-(dimethylamino)phenyl)diazenyl)phenyl)acetamido)acetate (1337956-60-1) → 2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-2-(4-((4'-(dimethylamino)phenyl)diazenyl)phenyl)acetamido)acetic acid (1337956-62-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1080/15257770.2011.604661

upstream raw materials:

2-(4-((4'-(dimethylamino)phenyl)diazenyl)phenyl)acetic acid

tert-butyl N-(2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}ethyl)glycinate

4-aminophenylacetic acid

Downstream raw materials:

2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-2-(4-((4'-(dimethylamino)phenyl)diazenyl)phenyl)acetamido)acetic acid