toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenyl) ester

Base Information

• Chemical Name: toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenyl) ester
• CAS No.: 207737-06-2
• Molecular Formula: C₁₉H₂₄O₃S₂
• Molecular Weight: 364.53
• Mol file: 207737-06-2.mol

Synonyms:toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenyl) ester

Chemical Property of toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenyl) ester

There total 14 articles about toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-tert-Butyl-5-methylphenol (88-60-8) → toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenyl) ester (207737-06-2)

Guidance literature:

Multi-step reaction with 8 steps

1: Br₂ / CCl₄

2: NaH / tetrahydrofuran

3: 1.) n-BuLi

4: H₂SO₄

5: 1.) NaH / 1.) DMF, 2.) DMF

6: 240 °C

7: DIBAL / CH₂Cl₂

8: pyridine / CCl₄

With pyridine; n-butyllithium; sulfuric acid; bromine; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; tetrachloromethane; dichloromethane;

DOI:10.1021/jm970522y

Reference yield:

4-Bromo-2-tert-butyl-5-methyl-phenol (51345-97-2) → toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenyl) ester (207737-06-2)

Guidance literature:

Multi-step reaction with 7 steps

1: NaH / tetrahydrofuran

2: 1.) n-BuLi

3: H₂SO₄

4: 1.) NaH / 1.) DMF, 2.) DMF

5: 240 °C

6: DIBAL / CH₂Cl₂

7: pyridine / CCl₄

With pyridine; n-butyllithium; sulfuric acid; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; tetrachloromethane; dichloromethane;

DOI:10.1021/jm970522y

Reference yield:

5-tert-Butyl-4-hydroxy-2-methyl-benzoic acid methyl ester (207737-02-8) → toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenyl) ester (207737-06-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 2.) DMF

2: 240 °C

3: DIBAL / CH₂Cl₂

4: pyridine / CCl₄

With pyridine; sodium hydride; diisobutylaluminium hydride; In tetrachloromethane; dichloromethane;

DOI:10.1021/jm970522y

upstream raw materials:

toluene-p-sulfonyl bromide

2-tert-Butyl-4-hydroxymethyl-5-methylthiophenol

p-toluenesulfonyl chloride

5-tert-Butyl-4-hydroxy-2-methylbenzaldehyde

Downstream raw materials:

3-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-[2-(4-hydroxy-phenyl)ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one

3-(tert-Butyl-4-hydroxymethyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-phenethyl-6-phenyl-5,6-dihydro-pyran-2-one

3-(2-tert-Butyl-4-hydroxymethyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-[2-(3-hydroxy-phenyl)-ethyl]-6-phenyl-5,6-dihydro-pyran-2-one

3-(2-tert-butyl-4-hydroxymethyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-phenyl-5,6-dihydro-pyran-2-one