2-[2-(2-methoxyethoxy)ethoxy]ethyl 3-bromo-4-methyl-5-trimethylsilanylethynylbenzoate

Base Information

Chemical Name:2-[2-(2-methoxyethoxy)ethoxy]ethyl 3-bromo-4-methyl-5-trimethylsilanylethynylbenzoate
CAS No.:905712-48-3
Molecular Formula:C₂₀H₂₉BrO₅Si
Molecular Weight:457.437
Hs Code.:

Synonyms:2-[2-(2-methoxyethoxy)ethoxy]ethyl 3-bromo-4-methyl-5-trimethylsilanylethynylbenzoate

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Chemical Property of 2-[2-(2-methoxyethoxy)ethoxy]ethyl 3-bromo-4-methyl-5-trimethylsilanylethynylbenzoate

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Technology Process of 2-[2-(2-methoxyethoxy)ethoxy]ethyl 3-bromo-4-methyl-5-trimethylsilanylethynylbenzoate

There total 4 articles about 2-[2-(2-methoxyethoxy)ethoxy]ethyl 3-bromo-4-methyl-5-trimethylsilanylethynylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.8%

: 905712-39-2
2-[2-(2-methoxyethoxy)ethoxy]ethyl 3-bromo-5-iodo-4-methyl-benzoate

: 1066-54-2
trimethylsilylacetylene

: 905712-48-3
2-[2-(2-methoxyethoxy)ethoxy]ethyl 3-bromo-4-methyl-5-trimethylsilanylethynylbenzoate

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1021/jo0607212

Reference yield:

: 905712-38-1
methyl 3-bromo-5-iodo-4-methyl-benzoate

: 905712-48-3
2-[2-(2-methoxyethoxy)ethoxy]ethyl 3-bromo-4-methyl-5-trimethylsilanylethynylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 61.1 percent / K₂CO₃ / 35 °C / 0.01 Torr

2: 87.8 percent / triethylamine / Pd(PPh₃)2Cl₂; CuI / tetrahydrofuran / 0.5 h / 20 °C

With potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; 2: Sonogashira cross-coupling;
DOI:10.1021/jo0607212

Reference yield:

: 112-35-6,95507-80-5
triethylene glucol monomethyl ether

: 905712-48-3
2-[2-(2-methoxyethoxy)ethoxy]ethyl 3-bromo-4-methyl-5-trimethylsilanylethynylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 61.1 percent / K₂CO₃ / 35 °C / 0.01 Torr

2: 87.8 percent / triethylamine / Pd(PPh₃)2Cl₂; CuI / tetrahydrofuran / 0.5 h / 20 °C

With potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; 2: Sonogashira cross-coupling;
DOI:10.1021/jo0607212