N-α--L-prolyl>-L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine

Base Information

• Chemical Name: N-α--L-prolyl>-L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine
• CAS No.: 130985-52-3
• Molecular Formula: C₄₇H₇₀N₉O₁₁P
• Molecular Weight: 968.1
• Mol file: 130985-52-3.mol

Synonyms:N-α--L-prolyl>-L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine

Chemical Property of N-α--L-prolyl>-L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-α--L-prolyl>-L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine

There total 3 articles about N-α--L-prolyl>-L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-α-acetyl>l-prolyl>-L-phenylalanyl>-Nα-methyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine (130985-40-9) → N-α--L-prolyl>-L-phenylalanyl>-Nα-methyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine (130985-52-3)

Guidance literature:

With hydrogenchloride; for 1h;

DOI:10.1021/jm00106a026

Reference yield:

(S)-Pyrrolidine-2-carboxylic acid ((S)-1-{[(S)-1-{(1S,2S,4S)-2-hydroxy-1-isobutyl-5-methyl-4-[(1S,2S)-2-methyl-1-(methyl-pyridin-2-yl-carbamoyl)-butylcarbamoyl]-hexylcarbamoyl}-2-(1H-imidazol-4-yl)-ethyl]-methyl-carbamoyl}-2-phenyl-ethyl)-amide → N-α--L-prolyl>-L-phenylalanyl>-Nα-methyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine (130985-52-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / diisopropylcarbodiimide / CH₂Cl₂ / 18 h

2: 95 percent / aq. HCl / 1 h

With hydrogenchloride; diisopropyl-carbodiimide; In dichloromethane;

DOI:10.1021/jm00106a026

Reference yield:

N-α--L-phenylalanyl>-Nα-methyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine (103336-05-6) → N-α--L-prolyl>-L-phenylalanyl>-Nα-methyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine (130985-52-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 177 mg / trifluoroacetic acid / CH₂Cl₂ / 1 h

2: 50 percent / diisopropylcarbodiimide / CH₂Cl₂ / 18 h

3: 95 percent / aq. HCl / 1 h

With hydrogenchloride; trifluoroacetic acid; diisopropyl-carbodiimide; In dichloromethane;

DOI:10.1021/jm00106a026

upstream raw materials:

N-α-acetyl>l-prolyl>-L-phenylalanyl>-N^α-methyl-L-histydyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine

N-α--L-phenylalanyl>-N^α-methyl-L-histidyl>-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine