2-(4-acetylphenoxy)-N-acetamidocolchicine

Base Information

Chemical Name:2-(4-acetylphenoxy)-N-acetamidocolchicine
CAS No.:725735-04-6
Molecular Formula:C₃₀H₃₁NO₈
Molecular Weight:533.578
Hs Code.:

Synonyms:2-(4-acetylphenoxy)-N-acetamidocolchicine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-acetylphenoxy)-N-acetamidocolchicine

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Technology Process of 2-(4-acetylphenoxy)-N-acetamidocolchicine

There total 4 articles about 2-(4-acetylphenoxy)-N-acetamidocolchicine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1878-81-5
4-acetylphenoxyacetic acid

: 3476-50-4
deacetylcolchicine

: 725735-04-6
2-(4-acetylphenoxy)-N-acetamidocolchicine

Guidance literature:: With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In chloroform; for 1.5h;
DOI:10.1021/jo049953w

Reference yield:

: 64-86-8,54192-66-4
colchicine

: 725735-04-6
2-(4-acetylphenoxy)-N-acetamidocolchicine

Guidance literature:: Multi-step reaction with 4 steps

1: 4-(dimethylamino)pyridine; triethylamine / acetonitrile / 3 h / 100 °C

2: CH₃OH; NaOCH₃ / 0.5 h / 20 °C

3: 542 mg / trifluoroacetic acid / 0.08 h

4: 84 percent / BOP; 4-methylmorpholine / CHCl₃ / 1.5 h

With 4-methyl-morpholine; methanol; dmap; sodium methylate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In chloroform; acetonitrile;
DOI:10.1021/jo049953w

Reference yield:

: 186374-95-8
(S)-tert-butyl N-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalene-7-yl)carbamate

: 725735-04-6
2-(4-acetylphenoxy)-N-acetamidocolchicine

Guidance literature:: Multi-step reaction with 2 steps

1: 542 mg / trifluoroacetic acid / 0.08 h

2: 84 percent / BOP; 4-methylmorpholine / CHCl₃ / 1.5 h

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; trifluoroacetic acid; In chloroform;
DOI:10.1021/jo049953w