methyl 3-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)propanoate

Base Information

Chemical Name:methyl 3-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)propanoate
CAS No.:937055-81-7
Molecular Formula:C₂₇H₂₈ClN₅O₅
Molecular Weight:538.003
Hs Code.:

Synonyms:methyl 3-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)propanoate

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Chemical Property of methyl 3-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)propanoate

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Technology Process of methyl 3-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)propanoate

There total 11 articles about methyl 3-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 134558-05-7
methyl 3-[2H-1,2,3,4-tetrazol-5-yl]propanoate

: 2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl methanesulfonate

: 937055-81-7
methyl 3-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)propanoate

: 937055-82-8
methyl 3-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3,4-tetrazol-5-yl)propanoate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937058-05-4
methyl 3-[2-(4-methoxybenzyl)-2H-1,2,3,4-tetrazol-5-yl]propanoate

: 937055-81-7
methyl 3-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)propanoate

: 937055-82-8
methyl 3-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3,4-tetrazol-5-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; 20% palladium hydroxide-activated charcoal; hydrogen / 1,4-dioxane; methanol / 6 h

2: tetra-(n-butyl)ammonium iodide; potassium carbonate

With hydrogenchloride; 20% palladium hydroxide-activated charcoal; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; In 1,4-dioxane; methanol;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937057-49-3
1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrole-2-carbaldehyde

: 937055-81-7
methyl 3-(2-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2H-1,2,3,4-tetrazol-5-yl)propanoate

: 937055-82-8
methyl 3-(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3,4-tetrazol-5-yl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: toluene / 7 h / 100 °C

2: sodium tetrahydroborate / methanol / 1 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

4: CHIRALCEL OD column / hexane; isopropyl alcohol / Resolution of racemate

5: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

6: triethylamine / dichloromethane / 3 h / 0 °C

7: tetra-(n-butyl)ammonium iodide; potassium carbonate

With sodium tetrahydroborate; lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; isopropyl alcohol; toluene; 1: Wittig reaction / 3: Michael reaction;
DOI:10.1016/j.bmc.2012.02.054