5-amino-2-{2-benzyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-benzoic acid

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Chemical Name:5-amino-2-{2-benzyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-benzoic acid
CAS No.:851046-18-9
Molecular Formula:C₃₂H₂₉N₇O₇
Molecular Weight:623.625
Hs Code.:

Synonyms:5-amino-2-{2-benzyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-benzoic acid

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Chemical Property of 5-amino-2-{2-benzyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-benzoic acid

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Technology Process of 5-amino-2-{2-benzyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-benzoic acid

There total 9 articles about 5-amino-2-{2-benzyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 851046-17-8
C₃₂H₂₇N₇O₉

: 851046-18-9
5-amino-2-{2-benzyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-benzoic acid

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methnol; for 6h;

Reference yield:

: 851046-14-5
5'-O-triisopropylsilyl-2',3'-di-O-isopropylidene adenosine

: 851046-18-9
5-amino-2-{2-benzyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene / 16 h / 25 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

3.1: acetic acid / tetrahydrofuran; 1,4-dioxane; water / 24 h / 50 °C

4.1: trifluoroacetic acid / 7 h / 0 °C / Molecular sieve

5.1: potassium tert-butylate / N,N-dimethyl-formamide

5.2: 2.5 h / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / methnol / 6 h

With potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; acetic acid; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methnol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1-[9-(6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-3-phenyl-urea

: 851046-18-9
5-amino-2-{2-benzyl-6-[6-(3-phenyl-ureido)-purin-9-yl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy}-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / tetrahydrofuran; 1,4-dioxane; water / 24 h / 50 °C

2.1: trifluoroacetic acid / 7 h / 0 °C / Molecular sieve

3.1: potassium tert-butylate / N,N-dimethyl-formamide

3.2: 2.5 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methnol / 6 h

With potassium tert-butylate; hydrogen; acetic acid; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methnol; water; N,N-dimethyl-formamide;