3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

Base Information

• Chemical Name: 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol
• CAS No.: 1620909-87-6
• Molecular Formula: C₃₇H₅₃N₃O₃Si
• Molecular Weight: 615.932

Synonyms:3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

Chemical Property of 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

Chemical Property:

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Technology Process of 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

There total 5 articles about 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-azido-4-tert-butylbenzene (18522-89-9) + 3-O-(tert-butyl)dimethylsilyl-2-methoxyethynylestradiol (1620910-47-5) → 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol (1620909-87-6)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 50 ℃; for 24h;

DOI:10.1016/j.steroids.2014.05.020

Reference yield:

p-tert-butylphenylboronic acid (123324-71-0) → 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol (1620909-87-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide; copper(ll) sulfate pentahydrate / methanol / 2 h / 40 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 50 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In methanol; water; tert-butyl alcohol;

DOI:10.1016/j.steroids.2014.05.020

Reference yield:

2-methoxyestrone (362-08-3,7683-30-9) → 3-O-(tert-butyl)dimethylsilyl-2-methoxy-17-(1-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol (1620909-87-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 4.75 h / 0 - 20 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 50 °C

With 1H-imidazole; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.steroids.2014.05.020

upstream raw materials:

p-tert-butylphenylboronic acid

2-methoxyestrone

3-O-(tert-butyl)dimethylsilyl-2-methoxyestrone

1-azido-4-tert-butylbenzene

Downstream raw materials:

2-methoxy-17-(1-(4-(tert-butyl)phenyl)-1H-1,2,3-triazol-4-yl)estradiol

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