(2S)-2-{[4-(2,2,2-trifluoro-1,1-dimethylethyl)phenoxy]methyl}-2,3-dihydro[1,3]oxazolo[3,2-a]benzimidazole

Base Information

Chemical Name:(2S)-2-{[4-(2,2,2-trifluoro-1,1-dimethylethyl)phenoxy]methyl}-2,3-dihydro[1,3]oxazolo[3,2-a]benzimidazole
CAS No.:1196124-60-3
Molecular Formula:C₂₀H₁₉F₃N₂O₂
Molecular Weight:376.378
Hs Code.:

Synonyms:(2S)-2-{[4-(2,2,2-trifluoro-1,1-dimethylethyl)phenoxy]methyl}-2,3-dihydro[1,3]oxazolo[3,2-a]benzimidazole

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Chemical Property of (2S)-2-{[4-(2,2,2-trifluoro-1,1-dimethylethyl)phenoxy]methyl}-2,3-dihydro[1,3]oxazolo[3,2-a]benzimidazole

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Technology Process of (2S)-2-{[4-(2,2,2-trifluoro-1,1-dimethylethyl)phenoxy]methyl}-2,3-dihydro[1,3]oxazolo[3,2-a]benzimidazole

There total 4 articles about (2S)-2-{[4-(2,2,2-trifluoro-1,1-dimethylethyl)phenoxy]methyl}-2,3-dihydro[1,3]oxazolo[3,2-a]benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 886843-09-0
4-(1,1,1-trifluoro-2-methylpropane-2-yl)phenol

: 1196125-46-8
(2S)-2,3-dihydro[1,3]oxazolo[3,2-a]benzimidazol-2-ylmethanol

: 1196124-60-3
(2S)-2-{[4-(2,2,2-trifluoro-1,1-dimethylethyl)phenoxy]methyl}-2,3-dihydro[1,3]oxazolo[3,2-a]benzimidazole

Guidance literature:: With di-isopropyl azodicarboxylate; In dichloromethane; at 25 ℃;

Reference yield:

: 4857-06-1
2-chloro-1H-benzoimidazole

: 1196124-60-3
(2S)-2-{[4-(2,2,2-trifluoro-1,1-dimethylethyl)phenoxy]methyl}-2,3-dihydro[1,3]oxazolo[3,2-a]benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere

1.2: 0 - 20 °C

2.1: hydrogen / palladium(II) hydroxide / methanol / 12 h / 37 °C

3.1: di-isopropyl azodicarboxylate / dichloromethane / 25 °C

With di-isopropyl azodicarboxylate; hydrogen; palladium(II) hydroxide; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1196125-22-0
(2S)-2-[(benzyloxy)methyl]-2,3-dihydro[1,3]oxazolo[3,2-a]benzimidazole

: 1196124-60-3
(2S)-2-{[4-(2,2,2-trifluoro-1,1-dimethylethyl)phenoxy]methyl}-2,3-dihydro[1,3]oxazolo[3,2-a]benzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium(II) hydroxide / methanol / 12 h / 37 °C

2: di-isopropyl azodicarboxylate / dichloromethane / 25 °C

With di-isopropyl azodicarboxylate; hydrogen; palladium(II) hydroxide; In methanol; dichloromethane;