(6R,7R)-3-Acetoxymethyl-8-oxo-7-{3-[1-phenyl-meth-(E)-ylideneaminooxy]-propionylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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Chemical Name:(6R,7R)-3-Acetoxymethyl-8-oxo-7-{3-[1-phenyl-meth-(E)-ylideneaminooxy]-propionylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No.:119881-25-3
Molecular Formula:C₂₀H₂₁N₃O₇S
Molecular Weight:447.469
Hs Code.:

Synonyms:(6R,7R)-3-Acetoxymethyl-8-oxo-7-{3-[1-phenyl-meth-(E)-ylideneaminooxy]-propionylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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Chemical Property of (6R,7R)-3-Acetoxymethyl-8-oxo-7-{3-[1-phenyl-meth-(E)-ylideneaminooxy]-propionylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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Technology Process of (6R,7R)-3-Acetoxymethyl-8-oxo-7-{3-[1-phenyl-meth-(E)-ylideneaminooxy]-propionylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

There total 4 articles about (6R,7R)-3-Acetoxymethyl-8-oxo-7-{3-[1-phenyl-meth-(E)-ylideneaminooxy]-propionylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 957-68-6
7-Aminocephalosporanic acid

: C₁₃H₁₅NO₅

: 119881-25-3
(6R,7R)-3-Acetoxymethyl-8-oxo-7-{3-[1-phenyl-meth-(E)-ylideneaminooxy]-propionylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 1.) 0 deg C, 1 h, 2.) 20 deg C, 15 min;
DOI:10.1021/jm00126a041

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 119881-25-3
(6R,7R)-3-Acetoxymethyl-8-oxo-7-{3-[1-phenyl-meth-(E)-ylideneaminooxy]-propionylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 45 percent / 2 N ethanolic KOH / ethanol / 48 h / 35 °C

2: 84 percent / KOH / ethanol / 48 h / Ambient temperature

3: triethylamine / CHCl₃; dioxane / 0.5 h / -10 °C

4: 37 percent / triethylamine / tetrahydrofuran; dimethylformamide / 1.) 0 deg C, 1 h, 2.) 20 deg C, 15 min

With potassium hydroxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00126a041

Reference yield:

: 103586-48-7
3-[1-Phenyl-meth-(E)-ylideneaminooxy]-propionic acid ethyl ester

: 119881-25-3
(6R,7R)-3-Acetoxymethyl-8-oxo-7-{3-[1-phenyl-meth-(E)-ylideneaminooxy]-propionylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / KOH / ethanol / 48 h / Ambient temperature

2: triethylamine / CHCl₃; dioxane / 0.5 h / -10 °C

3: 37 percent / triethylamine / tetrahydrofuran; dimethylformamide / 1.) 0 deg C, 1 h, 2.) 20 deg C, 15 min

With potassium hydroxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00126a041