(1-(2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-1,2,3-triazol-4-yl)methanol

Base Information

Chemical Name:(1-(2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-1,2,3-triazol-4-yl)methanol
CAS No.:1301629-07-1
Molecular Formula:C₁₈H₁₆Cl₃N₃O₂
Molecular Weight:412.703
Hs Code.:

Synonyms:(1-(2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-1,2,3-triazol-4-yl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1-(2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-1,2,3-triazol-4-yl)methanol

Chemical Property:

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Technology Process of (1-(2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-1,2,3-triazol-4-yl)methanol

There total 3 articles about (1-(2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-1,2,3-triazol-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1301629-38-8
1-(2-azido-1-(4-chlorobenzyloxy)ethyl)-2,4-dichlorobenzene

: 107-19-7
propargyl alcohol

: 1301629-07-1
(1-(2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-1,2,3-triazol-4-yl)methanol

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 150 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1016/j.bmcl.2012.09.041

Reference yield:

: 13692-14-3,114446-57-0
α-(chloromethyl)-2,4-dichlorobenzyl alcohol

: 1301629-07-1
(1-(2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-1,2,3-triazol-4-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 12 h / Reflux

2: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / 5 h / -78 - 20 °C / Inert atmosphere

3: copper(l) iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 150 °C / Microwave irradiation

With copper(l) iodide; sodium azide; tetra-(n-butyl)ammonium iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2012.09.041

Reference yield:

: 1301629-37-7
2-azido-1-(2,4-dichlorophenyl)ethan-1-ol

: 1301629-07-1
(1-(2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-1,2,3-triazol-4-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / 5 h / -78 - 20 °C / Inert atmosphere

2: copper(l) iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 150 °C / Microwave irradiation

With copper(l) iodide; tetra-(n-butyl)ammonium iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2012.09.041