4''-O-((4-(3,5-dinitrobenzamido)butyl)carbamoyl)azithromycin 11,12-carbonate

Base Information

Chemical Name:4''-O-((4-(3,5-dinitrobenzamido)butyl)carbamoyl)azithromycin 11,12-carbonate
CAS No.:1338923-74-2
Molecular Formula:C₅₁H₈₂N₆O₁₉
Molecular Weight:1083.24
Hs Code.:

Synonyms:4''-O-((4-(3,5-dinitrobenzamido)butyl)carbamoyl)azithromycin 11,12-carbonate

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Chemical Property of 4''-O-((4-(3,5-dinitrobenzamido)butyl)carbamoyl)azithromycin 11,12-carbonate

Chemical Property:

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Technology Process of 4''-O-((4-(3,5-dinitrobenzamido)butyl)carbamoyl)azithromycin 11,12-carbonate

There total 4 articles about 4''-O-((4-(3,5-dinitrobenzamido)butyl)carbamoyl)azithromycin 11,12-carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₃H₈₄N₆O₂₀

: 1338923-74-2
4''-O-((4-(3,5-dinitrobenzamido)butyl)carbamoyl)azithromycin 11,12-carbonate

Guidance literature:: With methanol; at 55 ℃; for 12h;
DOI:10.1016/j.ejmech.2011.08.001

Reference yield:

: 959852-67-6
(2S,3S,4R,6R)-6-{[(3aR,4R,7R,8S,9S,10R,11R,13R,16R,16aR)-10-{[(2S,3R,4S,6R)-3-(acetyloxy)-4-(dimethylamino)-6-methyloxan-2-yl]oxy}-4-ethyl-11-hydroxy-3a,7,9,11,13,15,16-heptamethyl-2,6-dioxo-tetradecahydro-1H-[1,3]dioxolo[4,5-c]-1-oxa-6-azacyclopentadecan-8-yl]oxy}-4-methoxy-2,4-dimethyloxan-3-yl 1H-imidazole-1-carboxylate

: 1338923-74-2
4''-O-((4-(3,5-dinitrobenzamido)butyl)carbamoyl)azithromycin 11,12-carbonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine / N,N-dimethyl-formamide / 4 h / 20 °C

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 0 °C

2.2: 2 h / 20 °C

3.1: methanol / 12 h / 55 °C

With methanol; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.08.001

Reference yield:

: 83905-01-5,92470-27-4
Zithromax(R)

: 1338923-74-2
4''-O-((4-(3,5-dinitrobenzamido)butyl)carbamoyl)azithromycin 11,12-carbonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 24 h / 20 °C

2.1: triethylamine / toluene / 48 h / 55 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine / N,N-dimethyl-formamide / 4 h / 20 °C

4.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 0 °C

4.2: 2 h / 20 °C

5.1: methanol / 12 h / 55 °C

With methanol; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2011.08.001