(4R,5S)-4-(4-benzyloxyphenyl)-3-(4-fluorophenyl)-2-hydroxymethyloxazolidin-2-one

Base Information

• Chemical Name: (4R,5S)-4-(4-benzyloxyphenyl)-3-(4-fluorophenyl)-2-hydroxymethyloxazolidin-2-one
• CAS No.: 795306-91-1
• Molecular Formula: C₂₃H₂₀FNO₄
• Molecular Weight: 393.415

Synonyms:(4R,5S)-4-(4-benzyloxyphenyl)-3-(4-fluorophenyl)-2-hydroxymethyloxazolidin-2-one

Chemical Property of (4R,5S)-4-(4-benzyloxyphenyl)-3-(4-fluorophenyl)-2-hydroxymethyloxazolidin-2-one

Chemical Property:

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Technology Process of (4R,5S)-4-(4-benzyloxyphenyl)-3-(4-fluorophenyl)-2-hydroxymethyloxazolidin-2-one

There total 7 articles about (4R,5S)-4-(4-benzyloxyphenyl)-3-(4-fluorophenyl)-2-hydroxymethyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(4R,5S)-4-(4-benzyloxyphenyl)-3-(4-fluorophenyl)-2-oxooxazolidine-5-carboxylic acid methyl ester (795306-90-0) → (4R,5S)-4-(4-benzyloxyphenyl)-3-(4-fluorophenyl)-2-hydroxymethyloxazolidin-2-one (795306-91-1)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 23 ℃; for 2h;

DOI:10.1039/b510100j

Reference yield: 80.0%

→ (4R,5S)-4-(4-benzyloxyphenyl)-3-(4-fluorophenyl)-2-hydroxymethyloxazolidin-2-one (795306-91-1)

Guidance literature:

Reference yield: 68.0%

4R-(4-benzyloxyphenyl)-3-(4-fluorophenyl)-2-oxo-oxazolidine-5S-carboxylic acid (1011265-03-4) → (4R,5S)-4-(4-benzyloxyphenyl)-3-(4-fluorophenyl)-2-hydroxymethyloxazolidin-2-one (795306-91-1)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 25 ℃; for 16h;

DOI:10.1016/j.bmcl.2007.11.083

upstream raw materials:

(4R,5S)-4-(4-benzyloxyphenyl)-3-(4-fluorophenyl)-2-oxooxazolidine-5-carboxylic acid methyl ester

(3S,4R)-2-(4-benzyloxyphenyl)-1-(4-fluorophenyl)-3-hydroxyazetidin-2-one

(2S,3R)-3-(4-benzyloxyphenyl)-3-(4-fluorophenyl)-2-hydroxypropionic acid methyl ester

(2S,5R,6S)-2-[(2R,3S)-2-(4-benzyloxyphenyl)-1-(4-fluorophenyl)-4-oxocyclobutoxy]-2,4,5-trimethyl-6-phenylmorpholin-3-one

Downstream raw materials:

(4R,5R)-4-(4-benzyloxyphenyl)-3-(4-fluorophenyl)-5-[(E)-3-(4-fluorophenyl)-3-oxopropenyl]oxazolidin-2-one

(4R,5R)-4-(4-Benzyloxy-phenyl)-3-(4-fluoro-phenyl)-5-[3-(4-fluoro-phenyl)-3-oxo-propyl]-oxazolidin-2-one

(4R,5R)-5-(azidomethyl)-4-(4-(benzyloxy)phenyl)-3-(4-fluorophenyl)oxazolidin-2-one

C₂₄H₂₂FNO₆S

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