4-nitrobenzyl (6R,7S)-3-methyl-7-methylthio-7-(4-nitrobenzylidene)aminoceph-3-em-4-carboxylate

Base Information

• Chemical Name: 4-nitrobenzyl (6R,7S)-3-methyl-7-methylthio-7-(4-nitrobenzylidene)aminoceph-3-em-4-carboxylate
• CAS No.: 95107-20-3
• Molecular Formula: C₂₃H₂₀N₄O₇S₂
• Molecular Weight: 528.566
• Mol file: 95107-20-3.mol

Synonyms:4-nitrobenzyl (6R,7S)-3-methyl-7-methylthio-7-(4-nitrobenzylidene)aminoceph-3-em-4-carboxylate

Chemical Property of 4-nitrobenzyl (6R,7S)-3-methyl-7-methylthio-7-(4-nitrobenzylidene)aminoceph-3-em-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nitrobenzyl (6R,7S)-3-methyl-7-methylthio-7-(4-nitrobenzylidene)aminoceph-3-em-4-carboxylate

There total 4 articles about 4-nitrobenzyl (6R,7S)-3-methyl-7-methylthio-7-(4-nitrobenzylidene)aminoceph-3-em-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(6R,7S)-7-methylthio-7-(4-nitrobenzylidene)amino-3-methylceph-3-em-4-carboxylic acid (95107-18-9) + 1-bromomethyl-4-nitro-benzene (100-11-8) → 4-nitrobenzyl (6R,7S)-3-methyl-7-methylthio-7-(4-nitrobenzylidene)aminoceph-3-em-4-carboxylate (95107-20-3)

Guidance literature:

With potassium hydrogencarbonate; In N,N-dimethyl-formamide; Ambient temperature;

Reference yield:

3-deacetyloxy-7-aminocephalosporanic acid (22252-43-3,26395-99-3,70287-30-8,72059-35-9) → 4-nitrobenzyl (6R,7S)-3-methyl-7-methylthio-7-(4-nitrobenzylidene)aminoceph-3-em-4-carboxylate (95107-20-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) CHCl₃, reflux, 1 h, 2.) CHCl₃, room temperature, 1.5 h

2: LDA / tetrahydrofuran; dimethylformamide / 1.) -75 deg C, 15 min, 2.) -70 deg C, 30 min

3: 99 percent / KHCO₃ / dimethylformamide / Ambient temperature

With potassium hydrogencarbonate; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

4-nitrobenzaldehdye (555-16-8) → 4-nitrobenzyl (6R,7S)-3-methyl-7-methylthio-7-(4-nitrobenzylidene)aminoceph-3-em-4-carboxylate (95107-20-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) CHCl₃, reflux, 1 h, 2.) CHCl₃, room temperature, 1.5 h

2: LDA / tetrahydrofuran; dimethylformamide / 1.) -75 deg C, 15 min, 2.) -70 deg C, 30 min

3: 99 percent / KHCO₃ / dimethylformamide / Ambient temperature

With potassium hydrogencarbonate; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

(6R,7S)-7-methylthio-7-(4-nitrobenzylidene)amino-3-methylceph-3-em-4-carboxylic acid

1-bromomethyl-4-nitro-benzene

3-deacetyloxy-7-aminocephalosporanic acid

4-nitrobenzaldehdye

Downstream raw materials:

4-nitrobenzyl (6R,7S)-7-amino-3-methyl-7-methylthioceph-3-em-4-carboxylate

4-nitrobenzyl (6R,7RS)-3',4'-dihydro-3-methyl-4'-oxospiro(2'H-1',3'-benzoxazine-2',7-ceph-3-em)-4-carboxylate

4-nitrobenzyl (2'R,6R,7S)-hydroxy(phenyl)acetylamino-7-methylthio-3-methylceph-3-em-4-carboxylate

4-nitrobenzyl (6R,7S)-7-(2-hydroxybenzoylamino)-3-methyl-7-methylthioceph-3-em-4-carboxylate