10-(furan-2-yl)-7-(4-nitrophenylsulfonyl)-7-azaspiro[4.5]decane-1,6,8-trione

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Chemical Name:10-(furan-2-yl)-7-(4-nitrophenylsulfonyl)-7-azaspiro[4.5]decane-1,6,8-trione
CAS No.:1584132-00-2
Molecular Formula:C₁₉H₁₆N₂O₈S
Molecular Weight:432.411
Hs Code.:

Synonyms:10-(furan-2-yl)-7-(4-nitrophenylsulfonyl)-7-azaspiro[4.5]decane-1,6,8-trione

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Chemical Property of 10-(furan-2-yl)-7-(4-nitrophenylsulfonyl)-7-azaspiro[4.5]decane-1,6,8-trione

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Technology Process of 10-(furan-2-yl)-7-(4-nitrophenylsulfonyl)-7-azaspiro[4.5]decane-1,6,8-trione

There total 5 articles about 10-(furan-2-yl)-7-(4-nitrophenylsulfonyl)-7-azaspiro[4.5]decane-1,6,8-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1201947-64-9
(E)-3-(furan-2-yl)acryloyl cyanide

: 1584132-15-9
N-(4-nitrophenylsulfonyl)-2-oxocyclopentanecarboxamide

: 1584132-00-2
10-(furan-2-yl)-7-(4-nitrophenylsulfonyl)-7-azaspiro[4.5]decane-1,6,8-trione

: 10-(furan-2-yl)-7-(4-nitrophenylsulfonyl)-7-azaspiro[4.5]decane-1,6,8-trione

Guidance literature:: With 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea; In m-xylene; at 0 ℃; for 40h; enantioselective reaction;
DOI:10.1002/chem.201303613

Reference yield:

: 6325-93-5
p-nitrobenzenesulfonamide

: 1584132-00-2
10-(furan-2-yl)-7-(4-nitrophenylsulfonyl)-7-azaspiro[4.5]decane-1,6,8-trione

: 10-(furan-2-yl)-7-(4-nitrophenylsulfonyl)-7-azaspiro[4.5]decane-1,6,8-trione

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 0.05 h / 160 °C / Microwave irradiation; Sealed tube

2: 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea / m-xylene / 40 h / 0 °C

With 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea; In m-xylene; toluene;
DOI:10.1002/chem.201303613

Reference yield:

: 539-47-9,15690-24-1
3-(fur-2-yl)crotonic acid

: 1584132-00-2
10-(furan-2-yl)-7-(4-nitrophenylsulfonyl)-7-azaspiro[4.5]decane-1,6,8-trione

: 10-(furan-2-yl)-7-(4-nitrophenylsulfonyl)-7-azaspiro[4.5]decane-1,6,8-trione

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux; Inert atmosphere

2: acetonitrile / 1 h / Reflux; Inert atmosphere

3: 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea / m-xylene / 40 h / 0 °C

With 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; m-xylene; acetonitrile;
DOI:10.1002/chem.201303613