2,2,2-trifluoro-N-(3-iodo-4-methoxyphenyl)acetamide

Base Information

Chemical Name:2,2,2-trifluoro-N-(3-iodo-4-methoxyphenyl)acetamide
CAS No.:261173-10-8
Molecular Formula:C₉H₇F₃INO₂
Molecular Weight:345.06
Hs Code.:
DSSTox Substance ID:DTXSID701222523

Synonyms:2,2,2-trifluoro-N-(3-iodo-4-methoxyphenyl)acetamide;ZBTCTRWLKJXMGD-UHFFFAOYSA-N;DTXSID701222523;261173-10-8

Suppliers and Price of 2,2,2-trifluoro-N-(3-iodo-4-methoxyphenyl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2,2-trifluoro-N-(3-iodo-4-methoxyphenyl)acetamide

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:344.94736
Heavy Atom Count:16
Complexity:260

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)NC(=O)C(F)(F)F)I

Technology Process of 2,2,2-trifluoro-N-(3-iodo-4-methoxyphenyl)acetamide

There total 3 articles about 2,2,2-trifluoro-N-(3-iodo-4-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 407-25-0
trifluoroacetic anhydride

: 261173-06-2
3-iodo-4-methoxyaniline hydrochloride

: 261173-10-8
2,2,2-trifluoro-N-(3-iodo-4-methoxyphenyl)acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 19h;
DOI:10.1002/(SICI)1099-1344(200001)43:1<29::AID-JLCR288>3.0.CO;2-R

Reference yield:

: 2,2,2-trifluoro-N-(3-iodo-4-methoxyphenyl)ethanimidoyl chloride

: 261173-10-8
2,2,2-trifluoro-N-(3-iodo-4-methoxyphenyl)acetamide

: 261173-12-0
1-(3-iodo-4-methoxyphenyl)-5-(trifluoromethyl)-1H-tetrazole

Guidance literature:: With sodium azide; In acetic acid; at 70 ℃; for 4h;
DOI:10.1002/(SICI)1099-1344(200001)43:1<29::AID-JLCR288>3.0.CO;2-R

Reference yield:

: 5399-03-1
2-iodo-1-methoxy-4-nitrobenzene

: 261173-10-8
2,2,2-trifluoro-N-(3-iodo-4-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / iron; acetic acid / methanol; H₂O / 1 h / 40 °C

2: 93 percent / triethylamine / CH₂Cl₂ / 19 h / 20 °C

With iron; acetic acid; triethylamine; In methanol; dichloromethane; water; 1: Reduction / 2: Acylation;
DOI:10.1002/(SICI)1099-1344(200001)43:1<29::AID-JLCR288>3.0.CO;2-R