L-Proline, 4-methyl-, methyl ester, cis- (9CI)

Base Information

• Chemical Name: L-Proline, 4-methyl-, methyl ester, cis- (9CI)
• CAS No.: 145730-69-4
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.186
• Mol file: 145730-69-4.mol

Synonyms:L-Proline, 4-methyl-, methyl ester, cis- (9CI)

Chemical Property of L-Proline, 4-methyl-, methyl ester, cis- (9CI)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Proline, 4-methyl-, methyl ester, cis- (9CI)

There total 19 articles about L-Proline, 4-methyl-, methyl ester, cis- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-N-benzyloxycarbonyl-4-methylenepyrrolidine-2-carboxylic acid methyl ester (200184-60-7) → (2S)-4-Methylproline Methyl Ester (443685-77-6,145730-69-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 2h;

Reference yield:

C14H19N3O5S → cis-L-4-methylproline methylester (145730-69-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h;

DOI:10.1039/c9ra06827a

Reference yield:

C20H32N2O4Si (1353864-33-1) → 4-methyl-pyrrolidine-2-carboxylic acid methyl ester (145730-69-4)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃; for 24h;

DOI:10.1021/ja210660g

upstream raw materials:

D-Glutamic acid

D‐α‐hydroxyglutaric acid

Downstream raw materials:

N-Boc-trans-4-methyl-L-proline benzyl ester

1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate

Refernces

• 1、 He, Gang,Zhao, Yingsheng,Zhang, Shuyu,Lu, Chengxi,Chen, Gong. "Highly efficient syntheses of azetidines, pyrrolidines, and indolines via palladium catalyzed intramolecular amination of C(sp3)-H and C(sp2)-H bonds at γ and δ positions". . p. 3 - 6. Retrieved 2012/02/16.
• 2、 -. "Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses". Page 207. . Retrieved 2010/11/30.