6-(1H-indol-5-yl)-N₄-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: 6-(1H-indol-5-yl)-N₄-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine
• CAS No.: 912471-74-0
• Molecular Formula: C₂₄H₁₇F₃N₆O
• Molecular Weight: 462.434

Synonyms:6-(1H-indol-5-yl)-N₄-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine

Chemical Property of 6-(1H-indol-5-yl)-N₄-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of 6-(1H-indol-5-yl)-N₄-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine

There total 1 articles about 6-(1H-indol-5-yl)-N₄-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-chloro-N4-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine (850250-76-9) + 1H-indole-5-boronic acid (144104-59-6) → 6-(1H-indol-5-yl)-N4-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine (912471-74-0)

Guidance literature:

With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl acetamide; at 120 ℃;

Reference yield: 6.3%

morpholine (110-91-8,99108-56-2) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 6-(1H-indol-5-yl)-N4-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine (912471-74-0) → 6-[3-(morpholin-4-ylmethyl)-1H-indol-5-yl]-N4-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine (912471-75-1)

Guidance literature:

morpholine; formaldehyd; 6-(1H-indol-5-yl)-N₄-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine; With acetic acid; In dichloromethane; water;

With sodium hydroxide; In dichloromethane; water;

upstream raw materials:

6-chloro-N₄-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine

1H-indole-5-boronic acid

Downstream raw materials:

6-[3-(morpholin-4-ylmethyl)-1H-indol-5-yl]-N₄-(4-{[2-(trifluoromethyl)pyridin-4-yl]oxy}phenyl)pyrimidine-2,4-diamine

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