C₂₅H₃₃NO₂S

Base Information

• Chemical Name: C₂₅H₃₃NO₂S
• CAS No.: 1383385-62-3
• Molecular Formula: C₂₅H₃₃NO₂S
• Molecular Weight: 411.609
• Mol file: 1383385-62-3.mol

Synonyms:C₂₅H₃₃NO₂S

Chemical Property of C₂₅H₃₃NO₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₃₃NO₂S

There total 11 articles about C₂₅H₃₃NO₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H24INO2S (1383385-33-8) + 1-methyl-1-(trimethylsilylethynyl)cyclopropane (158362-52-8) → C25H33NO2S (1383385-62-3)

Guidance literature:

With potassium fluoride; copper(l) iodide; benzyltrimethylammonium chloride; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 90 ℃; for 1h;

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → C25H33NO2S (1383385-62-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 8 h / -78 °C / Inert atmosphere

2.1: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C / Inert atmosphere

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 4 h / 92 °C / Inert atmosphere

4.1: acetonitrile / 3 h / 80 °C

5.1: sodium tetrahydroborate / methanol / 20 - 80 °C

6.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 2.5 h / -77 - -70 °C / Inert atmosphere

6.2: 1.5 h / -77 - -70 °C / Inert atmosphere

7.1: triethylamine; benzyltrimethylammonium chloride; potassium fluoride; copper(l) iodide / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 1 h / 90 °C

With potassium fluoride; sodium tetrahydroborate; copper(l) iodide; potassium acetate; sodium hexamethyldisilazane; benzyltrimethylammonium chloride; sodium carbonate; triethylamine; lithium diisopropyl amide; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; n-heptane; ethylbenzene; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

Methyl 3-aminothiophene-2-carboxylate (22288-78-4) → C25H33NO2S (1383385-62-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: diiodomethane; tert.-butylnitrite / acetonitrile / 1.5 h / 50 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 3 h / 88 °C / Inert atmosphere

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 4 h / 92 °C / Inert atmosphere

4.1: acetonitrile / 3 h / 80 °C

5.1: sodium tetrahydroborate / methanol / 20 - 80 °C

6.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 2.5 h / -77 - -70 °C / Inert atmosphere

6.2: 1.5 h / -77 - -70 °C / Inert atmosphere

7.1: triethylamine; benzyltrimethylammonium chloride; potassium fluoride; copper(l) iodide / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 1 h / 90 °C

With potassium fluoride; sodium tetrahydroborate; copper(l) iodide; tert.-butylnitrite; diiodomethane; benzyltrimethylammonium chloride; sodium carbonate; triethylamine; lithium diisopropyl amide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; n-heptane; ethylbenzene; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

cyclohexanone

Methyl 3-aminothiophene-2-carboxylate

(2-cyclopropylethynyl)trimethylsilane

4-methylcyclohex-1-en-1-yl trifluoromethanesulfonate

Refernces