6-formyl-5-phenyl-5-vinylhexanoic acid, 2,3-dihydro-4-methyl-2-thioxothiazol-3-yl ester

Base Information

Chemical Name:6-formyl-5-phenyl-5-vinylhexanoic acid, 2,3-dihydro-4-methyl-2-thioxothiazol-3-yl ester
CAS No.:134757-09-8
Molecular Formula:C₁₉H₂₁NO₃S₂
Molecular Weight:375.513
Hs Code.:

Synonyms:6-formyl-5-phenyl-5-vinylhexanoic acid, 2,3-dihydro-4-methyl-2-thioxothiazol-3-yl ester

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Chemical Property of 6-formyl-5-phenyl-5-vinylhexanoic acid, 2,3-dihydro-4-methyl-2-thioxothiazol-3-yl ester

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Technology Process of 6-formyl-5-phenyl-5-vinylhexanoic acid, 2,3-dihydro-4-methyl-2-thioxothiazol-3-yl ester

There total 9 articles about 6-formyl-5-phenyl-5-vinylhexanoic acid, 2,3-dihydro-4-methyl-2-thioxothiazol-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108212-22-2
6-iodo-3-phenyl-3-vinylhexanal

: 134757-09-8
6-formyl-5-phenyl-5-vinylhexanoic acid, 2,3-dihydro-4-methyl-2-thioxothiazol-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / p-toluenesulfonic acid / benzene / 12 h / Heating

2: 80 percent / dimethylsulfoxide / 3 h / 120 °C

3: 69 percent / 30percent aq. KOH, 30percent H₂O₂ / 1.) 40 deg C, 1 h, 2.) 111 deg C, 3 h

4: 90 percent / 10percent aq. HClO₄ / diethyl ether / 2 h / Ambient temperature

5: oxalyl chloride, dimethylformamide / benzene / 0.5 h / Ambient temperature

6: pyridine, 4-(dimethylamino)pyridine / diethyl ether / 0.5 h

With pyridine; dmap; potassium hydroxide; perchloric acid; oxalyl dichloride; dihydrogen peroxide; toluene-4-sulfonic acid; N,N-dimethyl-formamide; In diethyl ether; dimethyl sulfoxide; benzene;
DOI:10.1021/ja00015a037

Reference yield:

: 134756-94-8
6-formyl-5-phenyl-5-vinylhexanoic acid

: 134757-09-8
6-formyl-5-phenyl-5-vinylhexanoic acid, 2,3-dihydro-4-methyl-2-thioxothiazol-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride, dimethylformamide / benzene / 0.5 h / Ambient temperature

2: pyridine, 4-(dimethylamino)pyridine / diethyl ether / 0.5 h

With pyridine; dmap; oxalyl dichloride; N,N-dimethyl-formamide; In diethyl ether; benzene;
DOI:10.1021/ja00015a037

Reference yield:

: 2-(5-Iodo-2-phenyl-2-vinyl-pentyl)-[1,3]dioxolane

: 134757-09-8
6-formyl-5-phenyl-5-vinylhexanoic acid, 2,3-dihydro-4-methyl-2-thioxothiazol-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / dimethylsulfoxide / 3 h / 120 °C

2: 69 percent / 30percent aq. KOH, 30percent H₂O₂ / 1.) 40 deg C, 1 h, 2.) 111 deg C, 3 h

3: 90 percent / 10percent aq. HClO₄ / diethyl ether / 2 h / Ambient temperature

4: oxalyl chloride, dimethylformamide / benzene / 0.5 h / Ambient temperature

5: pyridine, 4-(dimethylamino)pyridine / diethyl ether / 0.5 h

With pyridine; dmap; potassium hydroxide; perchloric acid; oxalyl dichloride; dihydrogen peroxide; N,N-dimethyl-formamide; In diethyl ether; dimethyl sulfoxide; benzene;
DOI:10.1021/ja00015a037