NSC68992

Base Information

• Chemical Name: NSC68992
• CAS No.: 934-26-9
• Molecular Formula: C₄H₆ClN₅
• Molecular Weight: 159.578
• Hs Code.: 2933990090
• Mol file: 934-26-9.mol

Synonyms:3(2H)-Pyridazinone,4-amino-6-chloro-, hydrazone (9CI); Pyridazine, 4-amino-6-chloro-3-hydrazino-(7CI,8CI); 4-Amino-6-chloro-3-hydrazinopyridazine; NSC 68992

Chemical Property of NSC68992

Chemical Property:

• Vapor Pressure: 2.92E-08mmHg at 25°C
• Melting Point: 190 °C(Solv: ethanol (64-17-5))
• Boiling Point: 449.2°C at 760 mmHg
• PKA: 4.96±0.40(Predicted)
• Flash Point: 225.5°C
• PSA: 93.08000
• Density: 1.649g/cm³
• LogP: 0.70120
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-3-hydrazinylpyridazin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Chloro-3-hydrazinylpyridazin-4-amine is used to synthesize heterocyclic ring system as potential purine antagonist.

Technology Process of NSC68992

There total 2 articles about NSC68992 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3,6-dichloropyridazin-4-amine (823-58-5) → 4-amino-6-chloro-3-hydrazinopyridazine (934-26-9)

Guidance literature:

With hydrazine hydrate; at 105 - 110 ℃; for 0.583333h; Inert atmosphere;

DOI:10.1021/jm401356t

Reference yield:

→ 4-amino-6-chloro-3-hydrazinopyridazine (934-26-9)

Guidance literature:

entspr. 3-Chloropyridazin (5), Hydrazin;

Reference yield: 82.0%

acetic acid (64-19-7,77671-22-8) + 4-amino-6-chloro-3-hydrazinopyridazine (934-26-9) → 6-chloro-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-amine (53085-52-2)

Guidance literature:

With potassium acetate; at 170 ℃; for 4h; Microwave irradiation; Sealed tube;

upstream raw materials:

3,6-dichloropyridazin-4-amine

Downstream raw materials:

3-chloro-5-aminopyridazine

6-chloro-1,2,4-triazolo<4,3-b>pyridazin-8-amine

6-chloro-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-amine