3-{[(16β,17β)-3-fluoro-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide

Base Information

Chemical Name:3-{[(16β,17β)-3-fluoro-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide
CAS No.:1401937-84-5
Molecular Formula:C₂₆H₃₀FNO₂
Molecular Weight:407.528
Hs Code.:

Synonyms:3-{[(16β,17β)-3-fluoro-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide

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Chemical Property of 3-{[(16β,17β)-3-fluoro-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide

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Technology Process of 3-{[(16β,17β)-3-fluoro-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide

There total 6 articles about 3-{[(16β,17β)-3-fluoro-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1401938-35-9
3-{(E)-[(16E,17β)-3-fluoro-17-hydroxyestra-1,3,5(10)trien-16-ylidene]methyl}benzamide

: 1401937-84-5
3-{[(16β,17β)-3-fluoro-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 48h; Inert atmosphere;

Reference yield:

: 126534-87-0
3-carboxamidobenzaldehyde

: 1401937-84-5
3-{[(16β,17β)-3-fluoro-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol; water / 1 h / Reflux

2: sodium tetrahydroborate; methanol / dichloromethane / 0.5 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; hydrogen; potassium hydroxide; palladium 10% on activated carbon; In ethanol; dichloromethane; water;

Reference yield:

: 5295-56-7
(8R,9S,13S,14S)-3-fluoro-13-methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-one

: 1401937-84-5
3-{[(16β,17β)-3-fluoro-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol; water / 1 h / Reflux

2: sodium tetrahydroborate; methanol / dichloromethane / 0.5 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; hydrogen; potassium hydroxide; palladium 10% on activated carbon; In ethanol; dichloromethane; water;