tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate acetate

Base Information

Chemical Name:tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate acetate
CAS No.:1165798-04-8
Molecular Formula:C₂H₄O₂*C₃₀H₃₈N₄O₃
Molecular Weight:562.709
Hs Code.:

Synonyms:tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate acetate

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Chemical Property of tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate acetate

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Technology Process of tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate acetate

There total 5 articles about tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1165800-57-6
C₄₅H₄₈N₄O₅

: 631-61-8,92206-38-7
ammonium acetate

: 1165798-04-8
tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate acetate

Guidance literature:: C₄₅H₄₈N₄O₅; With piperidine; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

ammonium acetate; In dimethyl sulfoxide; acetonitrile; for 0.5h; HPLC;
DOI:10.1016/j.bmc.2011.04.014

Reference yield:

: 1312812-93-3
C₁₇H₁₄N₂O₂

: 1165798-04-8
tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,4-dioxane; water / 36 h / 0 - 20 °C / Inert atmosphere

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 15 h / 20 °C / Inert atmosphere

3.1: piperidine / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

3.2: 0.5 h / HPLC

With piperidine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmc.2011.04.014

Reference yield:

: 5467-57-2
2-chloroquinoline-4-carboxylic acid

: 1165798-04-8
tert-butyl [(trans-4-{[({2-[4-(aminomethyl)phenyl]quinolin-4-yl}carbonyl)amino]methyl}cyclohexyl)methyl]carbamate acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.25 h / 140 °C / Inert atmosphere; Microwave irradiation

2.1: 1,4-dioxane; water / 36 h / 0 - 20 °C / Inert atmosphere

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 15 h / 20 °C / Inert atmosphere

4.1: piperidine / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

4.2: 0.5 h / HPLC

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In 1,4-dioxane; dichloromethane; water; 1.1: Suzuki coupling;
DOI:10.1016/j.bmc.2011.04.014