4,5-Bis(3-pyridinyloxy)phthalonitrile

Base Information

• Chemical Name: 4,5-Bis(3-pyridinyloxy)phthalonitrile
• CAS No.: 147699-68-1
• Molecular Formula: C₁₈H₁₀N₄O₂
• Molecular Weight: 314.303
• Mol file: 147699-68-1.mol

Synonyms:4,5-Bis(3-pyridinyloxy)-1,2-benzenedicarbonitrile

Chemical Property of 4,5-Bis(3-pyridinyloxy)phthalonitrile

Chemical Property:

• Boiling Point: 496.7±45.0 °C(Predicted)
• PKA: 4.24±0.10(Predicted)
• PSA: 91.82000
• Density: 1.38±0.1 g/cm3(Predicted)
• LogP: 3.80456

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-Bis(3-pyridinyloxy)phthalonitrile

There total 4 articles about 4,5-Bis(3-pyridinyloxy)phthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,5-dichlorophthalic anhydride (942-06-3) → 4,5-bis(pyridin-3-yloxy)phthalonitrile (147699-68-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / formamide / 3 h / Heating

2: 72 percent / 25-33percent NH₄OH / 48 h / Ambient temperature

3: 75 percent / SOCl₂, DMF / 1) 0 - 5 deg C, 5 h, 2) r.t., 24 h

4: 59 percent / K₂CO₃ / dimethylsulfoxide / 0.5 h / 90 °C

With ammonium hydroxide; thionyl chloride; potassium carbonate; formamide; N,N-dimethyl-formamide; In dimethyl sulfoxide;

Reference yield:

4,5-dichlorophthalimide (15997-89-4) → 4,5-bis(pyridin-3-yloxy)phthalonitrile (147699-68-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / 25-33percent NH₄OH / 48 h / Ambient temperature

2: 75 percent / SOCl₂, DMF / 1) 0 - 5 deg C, 5 h, 2) r.t., 24 h

3: 59 percent / K₂CO₃ / dimethylsulfoxide / 0.5 h / 90 °C

With ammonium hydroxide; thionyl chloride; potassium carbonate; N,N-dimethyl-formamide; In dimethyl sulfoxide;

Reference yield:

4,5-dichlorophthalic acid (56962-08-4) → 4,5-bis(pyridin-3-yloxy)phthalonitrile (147699-68-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 93 percent / acetic anhydride / 5 h / Heating

2: 98 percent / formamide / 3 h / Heating

3: 72 percent / 25-33percent NH₄OH / 48 h / Ambient temperature

4: 75 percent / SOCl₂, DMF / 1) 0 - 5 deg C, 5 h, 2) r.t., 24 h

5: 59 percent / K₂CO₃ / dimethylsulfoxide / 0.5 h / 90 °C

With ammonium hydroxide; thionyl chloride; acetic anhydride; potassium carbonate; formamide; N,N-dimethyl-formamide; In dimethyl sulfoxide;

upstream raw materials:

4,5-dichlorophthalic anhydride

4,5-dichlorophthalimide

4,5-dichlorophthalic acid

4,5-dichloro-1,2-benzenedicarboxamide