[(2-{4-[(Bis-ethoxycarbonylmethyl-carbamoyl)-methoxy]-2,5-diiodo-phenoxy}-acetyl)-ethoxycarbonylmethyl-amino]-acetic acid ethyl ester

Base Information

• Chemical Name: [(2-{4-[(Bis-ethoxycarbonylmethyl-carbamoyl)-methoxy]-2,5-diiodo-phenoxy}-acetyl)-ethoxycarbonylmethyl-amino]-acetic acid ethyl ester
• CAS No.: 505065-18-9
• Molecular Formula: C₂₆H₃₄I₂N₂O₁₂
• Molecular Weight: 820.371
• Mol file: 505065-18-9.mol

Synonyms:[(2-{4-[(Bis-ethoxycarbonylmethyl-carbamoyl)-methoxy]-2,5-diiodo-phenoxy}-acetyl)-ethoxycarbonylmethyl-amino]-acetic acid ethyl ester

Chemical Property of [(2-{4-[(Bis-ethoxycarbonylmethyl-carbamoyl)-methoxy]-2,5-diiodo-phenoxy}-acetyl)-ethoxycarbonylmethyl-amino]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(2-{4-[(Bis-ethoxycarbonylmethyl-carbamoyl)-methoxy]-2,5-diiodo-phenoxy}-acetyl)-ethoxycarbonylmethyl-amino]-acetic acid ethyl ester

There total 5 articles about [(2-{4-[(Bis-ethoxycarbonylmethyl-carbamoyl)-methoxy]-2,5-diiodo-phenoxy}-acetyl)-ethoxycarbonylmethyl-amino]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-diiodo-1,4-hydroquinone (13064-64-7) → [(2-{4-[(Bis-ethoxycarbonylmethyl-carbamoyl)-methoxy]-2,5-diiodo-phenoxy}-acetyl)-ethoxycarbonylmethyl-amino]-acetic acid ethyl ester (505065-18-9)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / butan-2-one / Heating

2: NaOH / methanol / Heating

3: oxalyl chloride / Heating

4: Et₃N / CH₂Cl₂

With sodium hydroxide; oxalyl dichloride; potassium carbonate; triethylamine; In methanol; dichloromethane; butanone;

DOI:10.1039/b209561k

Reference yield:

diethyl 2,2'-((2,5-diiodo-1,4-phenylene)bis(oxy))diacetate (377093-03-3) → [(2-{4-[(Bis-ethoxycarbonylmethyl-carbamoyl)-methoxy]-2,5-diiodo-phenoxy}-acetyl)-ethoxycarbonylmethyl-amino]-acetic acid ethyl ester (505065-18-9)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH / methanol / Heating

2: oxalyl chloride / Heating

3: Et₃N / CH₂Cl₂

With sodium hydroxide; oxalyl dichloride; triethylamine; In methanol; dichloromethane;

DOI:10.1039/b209561k

Reference yield:

2,2'-(2,5-diiodo-1,4-phenylene)bis(oxy)diethanoic acid (505065-16-7) → [(2-{4-[(Bis-ethoxycarbonylmethyl-carbamoyl)-methoxy]-2,5-diiodo-phenoxy}-acetyl)-ethoxycarbonylmethyl-amino]-acetic acid ethyl ester (505065-18-9)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / Heating

2: Et₃N / CH₂Cl₂

With oxalyl dichloride; triethylamine; In dichloromethane;

DOI:10.1039/b209561k

upstream raw materials:

Diethyl iminodiacetate

2,5-diiodo-1,4-hydroquinone

diethyl 2,2'-((2,5-diiodo-1,4-phenylene)bis(oxy))diacetate

2,2'-(2,5-diiodo-1,4-phenylene)bis(oxy)diethanoic acid

Downstream raw materials:

2-[4-({bis-[(2-hydroxy-1,1-bis-hydroxymethyl-ethylcarbamoyl)-methyl]-carbamoyl}-methoxy)-2,5-diiodo-phenoxy]-N,N-bis-[(2-hydroxy-1,1-bis-hydroxymethyl-ethylcarbamoyl)-methyl]-acetamide