(1'S,3'S,5'R)-5,5-dimethyl-3'-(3-cyclopentyloxy-4-methoxyphenyl)spiro[1,3-dioxine-2,7'-bicyclo[3.3.0]octane]

Base Information

Chemical Name:(1'S,3'S,5'R)-5,5-dimethyl-3'-(3-cyclopentyloxy-4-methoxyphenyl)spiro[1,3-dioxine-2,7'-bicyclo[3.3.0]octane]
CAS No.:439919-23-0
Molecular Formula:C₂₅H₃₆O₄
Molecular Weight:400.558
Hs Code.:

Synonyms:(1'S,3'S,5'R)-5,5-dimethyl-3'-(3-cyclopentyloxy-4-methoxyphenyl)spiro[1,3-dioxine-2,7'-bicyclo[3.3.0]octane]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1'S,3'S,5'R)-5,5-dimethyl-3'-(3-cyclopentyloxy-4-methoxyphenyl)spiro[1,3-dioxine-2,7'-bicyclo[3.3.0]octane]

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Technology Process of (1'S,3'S,5'R)-5,5-dimethyl-3'-(3-cyclopentyloxy-4-methoxyphenyl)spiro[1,3-dioxine-2,7'-bicyclo[3.3.0]octane]

There total 4 articles about (1'S,3'S,5'R)-5,5-dimethyl-3'-(3-cyclopentyloxy-4-methoxyphenyl)spiro[1,3-dioxine-2,7'-bicyclo[3.3.0]octane] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (1'SR,5'RS)-5,5-dimethyl-3'-(3-cyclopentyloxy-4-methoxyphenyl)spiro[1,3-dioxine-2,7'-bicyclo[3.3.0]octan-2'-en]

: 439919-23-0
(1'S,3'S,5'R)-5,5-dimethyl-3'-(3-cyclopentyloxy-4-methoxyphenyl)spiro[1,3-dioxine-2,7'-bicyclo[3.3.0]octane]

Guidance literature:: With hydrogen; palladium on activated charcoal; In 1,4-dioxane; for 3h; atmospheric pressure;
DOI:10.1016/j.bmc.2004.07.040

Reference yield:

: C₂₅H₃₆O₅

: 439919-23-0
(1'S,3'S,5'R)-5,5-dimethyl-3'-(3-cyclopentyloxy-4-methoxyphenyl)spiro[1,3-dioxine-2,7'-bicyclo[3.3.0]octane]

Guidance literature:: Multi-step reaction with 2 steps

1: 1.99 g / MsCl; Et₃N / CH₂Cl₂ / 24 h / 20 °C

2: 100 percent / H₂ / Pd/C / dioxane / 3 h / atmospheric pressure

With hydrogen; methanesulfonyl chloride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmc.2004.07.040

Reference yield:

: 112755-94-9,92007-37-9
(3a'R,6a'S)-5,5-dimethyltetrahydro-1'H-spiro[1,3-dioxane-2,2'-pentalen]-5'(3'H)-one

: 439919-23-0
(1'S,3'S,5'R)-5,5-dimethyl-3'-(3-cyclopentyloxy-4-methoxyphenyl)spiro[1,3-dioxine-2,7'-bicyclo[3.3.0]octane]

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi; CeCl₃ / tetrahydrofuran / -78 °C

1.2: 3.48 g / tetrahydrofuran / 3 h / -78 °C

2.1: 1.99 g / MsCl; Et₃N / CH₂Cl₂ / 24 h / 20 °C

3.1: 100 percent / H₂ / Pd/C / dioxane / 3 h / atmospheric pressure

With n-butyllithium; cerium(III) chloride; hydrogen; methanesulfonyl chloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmc.2004.07.040