1-amino-2-(2-benzylthio-4-chloro-5-methylbenzenesulfonyl)guanidine

Base Information

• Chemical Name: 1-amino-2-(2-benzylthio-4-chloro-5-methylbenzenesulfonyl)guanidine
• CAS No.: 519053-88-4
• Molecular Formula: C₁₅H₁₇ClN₄O₂S₂
• Molecular Weight: 384.911
• Mol file: 519053-88-4.mol

Synonyms:1-amino-2-(2-benzylthio-4-chloro-5-methylbenzenesulfonyl)guanidine

Chemical Property of 1-amino-2-(2-benzylthio-4-chloro-5-methylbenzenesulfonyl)guanidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-amino-2-(2-benzylthio-4-chloro-5-methylbenzenesulfonyl)guanidine

There total 5 articles about 1-amino-2-(2-benzylthio-4-chloro-5-methylbenzenesulfonyl)guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

N-(2-benzylthio-4-chloro-5-methyl-benzenesulfonyl)cyanamide potassium salt → 3-amino-2-(2-benzylthio-4-chloro-5-methylbenzenesulphonyl)guanidine (519053-88-4)

Guidance literature:

With sulfuric acid; hydrazine hydrate; In tetrachloromethane; for 24h; Heating;

Reference yield:

N-(2-benzylthio-4-chloro-5-methyl-benzenesulfonyl)cyanamide potassium salt → 1-amino-2-(2-benzylthio-4-chloro-5-methylbenzenesulfonyl)guanidine (519053-88-4)

Guidance literature:

With hydrazine hydrochloride; In toluene;

DOI:10.3987/COM-11-12164

Reference yield:

3-amino-6-chloro-7-methyl-1,4,2-benzodithiazine 1,1-dioxide (374728-09-3) → 1-amino-2-(2-benzylthio-4-chloro-5-methylbenzenesulfonyl)guanidine (519053-88-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / tetrahydrofuran

2: hydrazine hydro-chloride

With hydrazine hydro-chloride; potassium carbonate; In tetrahydrofuran;

DOI:10.1007/s00706-012-0849-7

upstream raw materials:

3-amino-6-chloro-7-methyl-1,4,2-benzodithiazine 1,1-dioxide

benzyl chloride

Downstream raw materials:

C₁₆H₁₅ClN₄O₃S₂

2-(benzylthio)-4-chloro-N-[4,5-dihydro-1-(4-methylphenylsulfonyl)-5-oxo-1H-1,2,4-triazol-3-yl]-5-methylbenzenesulfonamide

1-[2-(benzylthio)-4-chloro-5-methylphenylsulfonyl]-3-(4-methylphenylsulfonylamino)guanidine