4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-5,5-bitrideuteratedmethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide

Base Information

Chemical Name:4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-5,5-bitrideuteratedmethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide
CAS No.:951753-38-1
Molecular Formula:C₂₀H₁₅F₄N₅O₂S
Molecular Weight:465.431
Hs Code.:

Synonyms:4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-5,5-bitrideuteratedmethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide

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Chemical Property of 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-5,5-bitrideuteratedmethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide

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Technology Process of 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-5,5-bitrideuteratedmethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide

There total 8 articles about 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-5,5-bitrideuteratedmethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 573762-62-6
5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile

: 463-71-8
thiophosgene

: 4-((2-cyanopropan-2-yl)amino)-2-fluoro-N-trideuteratedmethyl-benzamide

: 951753-38-1
4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-5,5-bitrideuteratedmethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide

Guidance literature:: 5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile; thiophosgene; 4-((2-cyanopropan-2-yl)amino)-2-fluoro-N-trideuteratedmethyl-benzamide; In N,N-dimethyl acetamide; at 60 ℃; for 16h;

With hydrogenchloride; In methanol; N,N-dimethyl acetamide; water; Reflux;

Reference yield:

: 2-bromo-5-nitro-3-(trifluoromethyl)pyridine

: 951753-38-1
4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-5,5-bitrideuteratedmethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) cyanide / N,N-dimethyl-formamide / 4 h / 100 - 110 °C

2.1: iron; acetic acid / ethyl acetate / Reflux

3.1: N,N-dimethyl acetamide / 16 h / 60 °C

3.2: Reflux

With copper(l) cyanide; iron; acetic acid; In N,N-dimethyl acetamide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 403-24-7
2-fluoro-4-nitrobenzoic acid

: 951753-38-1
4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-5,5-bitrideuteratedmethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C

1.2: 1 h / 20 °C

2.1: iron; acetic acid / ethyl acetate / 16 h / Reflux

3.1: acetic acid / 16 h / 80 °C / Sealed tube

4.1: N,N-dimethyl acetamide / 16 h / 60 °C

4.2: Reflux

With iron; acetic acid; 1,1'-carbonyldiimidazole; In dichloromethane; N,N-dimethyl acetamide; ethyl acetate;