2-(5-ethylthiophen-2-yl)-6-fluoro-3-(4-fluorobenzyl)-2,3-dihydroquinazolin-4(1H)-one

Base Information

Chemical Name:2-(5-ethylthiophen-2-yl)-6-fluoro-3-(4-fluorobenzyl)-2,3-dihydroquinazolin-4(1H)-one
CAS No.:1542098-94-1
Molecular Formula:C₂₁H₁₈F₂N₂OS
Molecular Weight:384.45
Hs Code.:

Synonyms:2-(5-ethylthiophen-2-yl)-6-fluoro-3-(4-fluorobenzyl)-2,3-dihydroquinazolin-4(1H)-one

Suppliers and Price of 2-(5-ethylthiophen-2-yl)-6-fluoro-3-(4-fluorobenzyl)-2,3-dihydroquinazolin-4(1H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(5-ethylthiophen-2-yl)-6-fluoro-3-(4-fluorobenzyl)-2,3-dihydroquinazolin-4(1H)-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(5-ethylthiophen-2-yl)-6-fluoro-3-(4-fluorobenzyl)-2,3-dihydroquinazolin-4(1H)-one

There total 4 articles about 2-(5-ethylthiophen-2-yl)-6-fluoro-3-(4-fluorobenzyl)-2,3-dihydroquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 36880-33-8
5-ethyl-thiophene-2-carbaldehyde

: C₁₄H₁₂F₂N₂O

: 1542098-94-1
2-(5-ethylthiophen-2-yl)-6-fluoro-3-(4-fluorobenzyl)-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:: With scandium tris(trifluoromethanesulfonate); In methanol; at 100 ℃; for 1h; Microwave irradiation; Sealed tube;
DOI:10.1371/journal.pntd.0005556

Reference yield:

: 5-fluoro-N-(4-fluorobenzyl)-2-nitrobenzamide

: 1542098-94-1
2-(5-ethylthiophen-2-yl)-6-fluoro-3-(4-fluorobenzyl)-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; ammonium formate / methanol / 1 h

2: scandium tris(trifluoromethanesulfonate) / methanol / 1 h / 100 °C / Microwave irradiation

With palladium 10% on activated carbon; ammonium formate; scandium tris(trifluoromethanesulfonate); In methanol;
DOI:10.1016/j.bmc.2014.06.053

Reference yield:

: 320-98-9
5-fluoro-2-nitrobenzoic acid

: 1542098-94-1
2-(5-ethylthiophen-2-yl)-6-fluoro-3-(4-fluorobenzyl)-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: dicyclohexyl-carbodiimide / dichloromethane / 0.08 h / 20 °C

1.2: 16 h / 20 °C

2.1: palladium 10% on activated carbon; ammonium formate / methanol / 1 h

3.1: scandium tris(trifluoromethanesulfonate) / methanol / 1 h / 100 °C / Microwave irradiation

With palladium 10% on activated carbon; ammonium formate; dicyclohexyl-carbodiimide; scandium tris(trifluoromethanesulfonate); In methanol; dichloromethane;
DOI:10.1016/j.bmc.2014.06.053