2-(2-acetylhydrazino)-7-chloro-5-phenyl-3H-1,4-benzodiazepine

Base Information

• Chemical Name: 2-(2-acetylhydrazino)-7-chloro-5-phenyl-3H-1,4-benzodiazepine
• CAS No.: 28910-89-6
• Molecular Formula: C17H15 Cl N4 O
• Molecular Weight: 326.785
• Hs Code.: 2933997500
• European Community (EC) Number: 620-268-8
• UNII: 50V54399VP
• DSSTox Substance ID: DTXSID40183109
• Nikkaji Number: J506.210A
• Wikidata: Q27260827
• Mol file: 28910-89-6.mol

Synonyms:28910-89-6;2-(2-acetylhydrazino)-7-chloro-5-phenyl-3H-1,4-benzodiazepine;N'-(7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-yl)acetohydrazide;N'-(7-chloro-5-phenyl-3H-benzo[e][1,4]diazepin-2-yl)acetohydrazide;Acetic acid, 2-(7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-yl)hydrazide;UNII-50V54399VP;50V54399VP;SCHEMBL7331891;SCHEMBL8227353;DTXSID40183109;MFCD08460262;7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepine-2 acetylhydrazone;AKOS015963058;s11042;AC-18722;Q27260827;N\'-(7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-yl)acetohydrazide;2-(7-Chloro-5-phenyl-3H-1,4-benzodiazepin-2-yl)hydrazide Acetic Acid;N'-[(2E)-7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-ylidene]acetohydrazide #

Chemical Property of 2-(2-acetylhydrazino)-7-chloro-5-phenyl-3H-1,4-benzodiazepine

Chemical Property:

• Melting Point: 245-2470C
• PSA: 79.84000
• Density: 1.33g/cm3
• LogP: 2.60590
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 326.0934388
• Heavy Atom Count: 23
• Complexity: 499

Purity/Quality:

99.9% ^*data from raw suppliers

Alprazolam Related Compound A United States Pharmacopeia (USP) Reference Standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NNC1=NC2=C(C=C(C=C2)Cl)C(=NC1)C3=CC=CC=C3
• Uses: 2-(2-Acetylhydrazino)-7-chloro-5-phenyl-3H-1,4-benzodiazepine is an impurity of Alprazolam (A575650.

Technology Process of 2-(2-acetylhydrazino)-7-chloro-5-phenyl-3H-1,4-benzodiazepine

There total 4 articles about 2-(2-acetylhydrazino)-7-chloro-5-phenyl-3H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine (18091-89-9,112393-62-1) → 7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one acetylhydrazone (28910-89-6)

Guidance literature:

With sodium hydrogencarbonate; In methanol; chloroform; water;

Reference yield:

7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione (4547-02-8) → 7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one acetylhydrazone (28910-89-6)

Guidance literature:

In ethanol; dichloromethane;

Reference yield:

→ 7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one acetylhydrazone (28910-89-6)

Guidance literature:

7-Chlor-1,3-dihydro-5-phenyl-2H-1,4-benzo-diazepin-2-thion (28), Acethydrazid.;

DOI:10.1021/jm00293a015

upstream raw materials:

7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione

7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine

Downstream raw materials:

alprazolam

Refernces

• 1、 -. "6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines". . . Retrieved 2008/06/13.