5-Methyl-3-methanol-1H-pyrazol [1R-(1,2,5)]

Base Information

• Chemical Name: 5-Methyl-3-methanol-1H-pyrazol [1R-(1,2,5)]
• CAS No.: 29004-73-7
• Molecular Formula: C₅H₈N₂O
• Molecular Weight: 112.131
• Hs Code.: 2933199090
• Mol file: 29004-73-7.mol

Synonyms:Pyrazole-3-methanol,5-methyl- (8CI); 5-Carbinol-3-methylpyrazole

Chemical Property of 5-Methyl-3-methanol-1H-pyrazol [1R-(1,2,5)]

Chemical Property:

• Melting Point: 80-82 °C
• Boiling Point: 316.5±27.0 °C(Predicted)
• PKA: 13.61±0.10(Predicted)
• PSA: 48.91000
• Density: 1.231±0.06 g/cm3(Predicted)
• LogP: 0.21040
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(3-Methyl-1H-pyrazol-5-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (5-Methyl-1h-pyrazol-3-yl)methanol is a reactant used in the preparation of 3,5-disubstituted N-unsubstituted pyrazoles from protected alkynols.

Technology Process of 5-Methyl-3-methanol-1H-pyrazol [1R-(1,2,5)]

There total 4 articles about 5-Methyl-3-methanol-1H-pyrazol [1R-(1,2,5)] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methyl-3-[(tetrahydro-2H-pyran-2-yl)oxy]methylpyrazole (493038-46-3) → 5-methylpyrazole-3-methanol (29004-73-7)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; for 8h; Heating;

DOI:10.1021/jo026083e

Reference yield:

5-[(tetrahydro-2H-pyran-2-yl)oxy]pent-3-yn-2-one (52804-46-3) → 5-methylpyrazole-3-methanol (29004-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine monohydrate / methanol / 12 h

2: 3.89 g / p-TsOH*H₂O / methanol / 8 h / Heating

With toluene-4-sulfonic acid; hydrazine hydrate; In methanol;

DOI:10.1021/jo026083e

Reference yield:

ethyl 5-methyl-1H-pyrazole-3-carboxylate (4027-57-0) → 5-methylpyrazole-3-methanol (29004-73-7)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether;

DOI:10.1021/jo01374a004

upstream raw materials:

ethyl 5-methyl-1H-pyrazole-3-carboxylate

5-methyl-3-[(tetrahydro-2H-pyran-2-yl)oxy]methylpyrazole

5-[(tetrahydro-2H-pyran-2-yl)oxy]pent-3-yn-2-one

Downstream raw materials:

3-(diphenylphosphinomethyl)-5-methylpyrazole

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 29004-73-7 5-Methyl-3-methanol-1H-pyrazol [1R-(1,2,5)]

Send

Send

Metric Ton KG G Pound L ML

Send

Send