Technology Process of macakurzin C
There total 8 articles about macakurzin C which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
boron trichloride;
In
n-heptane; dichloromethane;
at 0 - 20 ℃;
for 2h;
DOI:10.1055/s-0034-1378904
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(l) chloride / acetonitrile / 14 h / 0 °C
2: N,N-diethylaniline / 1 h / 270 °C
3: boron trichloride / dichloromethane; n-heptane / 2 h / 0 - 20 °C
With
boron trichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-diethylaniline; copper(l) chloride;
In
n-heptane; dichloromethane; acetonitrile;
2: |Claisen Rearrangement;
DOI:10.1055/s-0034-1378904
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridinium p-toluenesulfonate / dichloromethane / 10 h / 20 °C
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 20 °C
2.2: 16 h / 0 °C
3.1: N,N-diethylaniline / 1 h / 270 °C
4.1: boron trichloride / dichloromethane; n-heptane / 2 h / 0 - 20 °C
With
pyridinium p-toluenesulfonate; boron trichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-diethylaniline;
In
n-heptane; dichloromethane; acetonitrile;
3.1: |Claisen Rearrangement;
DOI:10.1055/s-0034-1378904